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- W4313350080 abstract "Abstract Vgamma2Vdelta2 T cells in human peripheral blood recognize phosphoantigen and play important roles in host defense and immunoregulation. However, the molecular mechanisms responsible for phophogantigen-mediated activation of human gammadelta T-cells remain unclear. We have previously reported that phosphoantigen isopentyl pyrophosphate (IPP) activated MEK/Erk and PI-3K/Akt pathways rapidly. Specific inhibition of Erk and Akt significantly impaired the functional response to IPP. In the present study, we found that IL2 can also activate MEK/Erk and PI-3K/Akt pathways without inducing functional responses. When given together with IPP, the effect of IL2 was to enhance cytokines production, degranulation and cytotoxicity. These data implicate the activation of MEK/Erk and PI-3K/Akt pathways as necessary but not sufficient to induce functional responses in Vgamma2Vdelta2 T cells. Further, we found that FK506 or cyclosporine A (CsA) inhibitors of calcineurin, completely blocked IPP-induced cytokines production, and partly inhibited TCR-dependent degranulation and cytotoxicity functions of Vgamma2Vdelta2 T cells. IPP but not IL2 induced the calcium-dependent nuclear translocation of NFAT. Our results indicate that calcium signaling pathway plays a crucial role in TCR-dependent functions in Vgamma2Vdelta2 T cells that can be distinguished from the effect of IL2." @default.
- W4313350080 created "2023-01-06" @default.
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- W4313350080 date "2010-04-01" @default.
- W4313350080 modified "2023-09-30" @default.
- W4313350080 title "Crucial role of calcium signaling in TCR-dependent functions of Vgamma2Vdelta2 T cell (89.23)" @default.
- W4313350080 doi "https://doi.org/10.4049/jimmunol.184.supp.89.23" @default.
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