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- W4313350083 abstract "Abstract Human myeloid cells contain several phenotypically and functionally distinct subpopulations. Among these are myeloid derived suppressor cells (MDSC), which are identified as CD11b+Gr-1+ in mice, but are more heterogeneous in humans. A clear consensus does not exist regarding the phenotypic definition of human MDSC, but some have described them as CD33+CD11b+CD14- HLA DR- cells, within which granulocytic MDSC express CD15, whereas monocytic MDSC express CD66b. More studies are needed to characterize and delineate MDSC subsets in humans. Here we report a preliminary study of myeloid subsets found within a monocyte fraction elutriated from apheresis samples of pediatric cancer patients vs healthy controls. In 4 of 20 pediatric cancer patients studied, we observed accumulation of CD14-CD123-CD11cint or hi cells, which were not present in healthy donors. Further analysis of these abnormal myeloid populations revealed HLA DR+CD127+CD15+CD66b+CD124+ as well as CD68+CD11b+PDL1+, but CD33lo or -. Histologic examination showed these were immature neutrophils and eosinophils. Functional studies demonstrated diminished T cell proliferation in the presence of suboptimal concentrations of OKT3, compared to cultures with CD14+ monocytes and CD14-CD123+CD11c+ myeloid cells, which enhanced T cell proliferation. Studies are underway to further characterize function of this unique subset and to explore expression of suppressive mediators such as iNOS, arginase and IDO." @default.
- W4313350083 created "2023-01-06" @default.
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- W4313350083 date "2011-04-01" @default.
- W4313350083 modified "2023-09-27" @default.
- W4313350083 title "A novel subset of myeloid suppressor cells in pediatric cancer patients (66.9)" @default.
- W4313350083 doi "https://doi.org/10.4049/jimmunol.186.supp.66.9" @default.
- W4313350083 hasPublicationYear "2011" @default.
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