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- W4313350092 abstract "Abstract The precise mechanisms underlying the interaction between intestinal bacteria and the host epithelium lead to multiple consequences that remain poorly understood at the molecular level. Deciphering such events can provide valuable information as to the mode of action of commensal microorganisms in the gastrointestinal environment. Using human intestinal epithelial Caco-2 cell grown as polarized monolayers, we found that association of a Lactobacillus or a Bifidobacterium with nonspecific secretory IgA (SIgA) enhanced probiotic adhesion, increased the level of nuclear translocation of NF-kappaB and production of epithelial polymeric Ig receptor as compared to bacteria alone, whereas transepithelial electrical resistance remained stable. Following administration in mouse ligated ileal loops containing a Peyer’s patch, it was found that SIgA bound to Lactobacillus or Bifidobacterium is involved in translocation to underlying dendritic cells residing in the subepithelial dome (SED) region. This phenomenon was mediated by passage across M cells, and required exogenously delivered or endogenous SIgA, as free bacteria was not observed in the SED region. These findings add to the multiple functions of SIgA and underscore a novel role of the antibody in its complex cross-talk with the intestinal epithelium." @default.
- W4313350092 created "2023-01-06" @default.
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- W4313350092 date "2011-04-01" @default.
- W4313350092 modified "2023-10-18" @default.
- W4313350092 title "In vitro and in vivo role of SIgA in the interaction of commensals bacteria with the intestinal epithelium (59.9)" @default.
- W4313350092 doi "https://doi.org/10.4049/jimmunol.186.supp.59.9" @default.
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