Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313350095> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W4313350095 endingPage "76.7" @default.
- W4313350095 startingPage "76.7" @default.
- W4313350095 abstract "Abstract In 2009, the emergence of pandemic A influenza virus (pH1N1) demonstrated greater severity in pregnant women as recognized previously in other influenza pandemics. The Centers for Disease Control and Prevention reported a death rate of 20% in pregnant women in the United States who were hospitalized with influenza-like symptoms. To understand the immunological basis for the enhanced influenza-associated morbidity and mortality observed in pregnant women, pregnant and nonpregnant ferrets were challenged with aerosolized pH1N1 strain A/California/04/09. The pregnant ferrets had poorer gestational outcomes and presented a more rapid and severe clinical disease when compared to the nonpregnant ferret group. Viral load and tissue tropism were similar for both groups as determined by quantitative RT-PCR. Influenza virus was detected in the brains of both groups. Gross pathological analysis and H&E stains identified interstitial pneumonia in the lungs, with no significant pathology in any other tissues. Virus was also detected in placental tissue and kits of the pregnant ferrets suggesting transmission across the placental barrier. This model will be useful in discerning the differences in the host response to infection that results in greater morbidity and mortality during pregnancy." @default.
- W4313350095 created "2023-01-06" @default.
- W4313350095 creator A5006029809 @default.
- W4313350095 creator A5024108460 @default.
- W4313350095 creator A5042327033 @default.
- W4313350095 creator A5070045789 @default.
- W4313350095 creator A5079069067 @default.
- W4313350095 creator A5083487925 @default.
- W4313350095 date "2012-05-01" @default.
- W4313350095 modified "2023-09-27" @default.
- W4313350095 title "Aerosolized Influenza Infection During Late Gestation Pregnancy Results in Severe Clinical Outcomes in the Ferret Model (76.7)" @default.
- W4313350095 doi "https://doi.org/10.4049/jimmunol.188.supp.76.7" @default.
- W4313350095 hasPublicationYear "2012" @default.
- W4313350095 type Work @default.
- W4313350095 citedByCount "0" @default.
- W4313350095 crossrefType "journal-article" @default.
- W4313350095 hasAuthorship W4313350095A5006029809 @default.
- W4313350095 hasAuthorship W4313350095A5024108460 @default.
- W4313350095 hasAuthorship W4313350095A5042327033 @default.
- W4313350095 hasAuthorship W4313350095A5070045789 @default.
- W4313350095 hasAuthorship W4313350095A5079069067 @default.
- W4313350095 hasAuthorship W4313350095A5083487925 @default.
- W4313350095 hasConcept C126322002 @default.
- W4313350095 hasConcept C159047783 @default.
- W4313350095 hasConcept C203014093 @default.
- W4313350095 hasConcept C207886595 @default.
- W4313350095 hasConcept C2522874641 @default.
- W4313350095 hasConcept C2777546802 @default.
- W4313350095 hasConcept C2777914695 @default.
- W4313350095 hasConcept C2778376644 @default.
- W4313350095 hasConcept C2779134260 @default.
- W4313350095 hasConcept C2779234561 @default.
- W4313350095 hasConcept C3008058167 @default.
- W4313350095 hasConcept C33602714 @default.
- W4313350095 hasConcept C35693153 @default.
- W4313350095 hasConcept C42407357 @default.
- W4313350095 hasConcept C46973012 @default.
- W4313350095 hasConcept C524204448 @default.
- W4313350095 hasConcept C54355233 @default.
- W4313350095 hasConcept C71924100 @default.
- W4313350095 hasConcept C86803240 @default.
- W4313350095 hasConcept C89623803 @default.
- W4313350095 hasConceptScore W4313350095C126322002 @default.
- W4313350095 hasConceptScore W4313350095C159047783 @default.
- W4313350095 hasConceptScore W4313350095C203014093 @default.
- W4313350095 hasConceptScore W4313350095C207886595 @default.
- W4313350095 hasConceptScore W4313350095C2522874641 @default.
- W4313350095 hasConceptScore W4313350095C2777546802 @default.
- W4313350095 hasConceptScore W4313350095C2777914695 @default.
- W4313350095 hasConceptScore W4313350095C2778376644 @default.
- W4313350095 hasConceptScore W4313350095C2779134260 @default.
- W4313350095 hasConceptScore W4313350095C2779234561 @default.
- W4313350095 hasConceptScore W4313350095C3008058167 @default.
- W4313350095 hasConceptScore W4313350095C33602714 @default.
- W4313350095 hasConceptScore W4313350095C35693153 @default.
- W4313350095 hasConceptScore W4313350095C42407357 @default.
- W4313350095 hasConceptScore W4313350095C46973012 @default.
- W4313350095 hasConceptScore W4313350095C524204448 @default.
- W4313350095 hasConceptScore W4313350095C54355233 @default.
- W4313350095 hasConceptScore W4313350095C71924100 @default.
- W4313350095 hasConceptScore W4313350095C86803240 @default.
- W4313350095 hasConceptScore W4313350095C89623803 @default.
- W4313350095 hasIssue "1_Supplement" @default.
- W4313350095 hasLocation W43133500951 @default.
- W4313350095 hasOpenAccess W4313350095 @default.
- W4313350095 hasPrimaryLocation W43133500951 @default.
- W4313350095 hasRelatedWork W1971982748 @default.
- W4313350095 hasRelatedWork W2055084975 @default.
- W4313350095 hasRelatedWork W2135818260 @default.
- W4313350095 hasRelatedWork W2161322994 @default.
- W4313350095 hasRelatedWork W2605056859 @default.
- W4313350095 hasRelatedWork W2609767786 @default.
- W4313350095 hasRelatedWork W26441585 @default.
- W4313350095 hasRelatedWork W2926996005 @default.
- W4313350095 hasRelatedWork W2946588866 @default.
- W4313350095 hasRelatedWork W2948183856 @default.
- W4313350095 hasVolume "188" @default.
- W4313350095 isParatext "false" @default.
- W4313350095 isRetracted "false" @default.
- W4313350095 workType "article" @default.