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- W4313350097 abstract "Abstract Axl receptor tyrosine kinase has been known to play a crucial role in cell survival, proliferation, and migration, but little is yet known about its regulatory role in the generation of γδ T cells. Here we investigated the role of Axl in the generation of intraepithelial γδ T cells. The γδ T cell population was increased in intraepithelial lymphocytes (IELs) of Axl-/- mice compared to them of wild type mice. In addition, upregulaton of IL-7α Rexpression was observed in both IELs and γδ T cells purified from IELs of Axl-/- mice. In electrophoretic mobility shift assay, IELs of Axl-/- mice showed the reduced AP-1 activation due to the dephosphorylation of its upstream signaling molecules, c-Jun and JNK. Taken together, these results suggested that Axl is required for the generation of intestinal γδ T cells by the transcriptional regulation of IL-7Rα via the JNK pathway." @default.
- W4313350097 created "2023-01-06" @default.
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- W4313350097 date "2011-04-01" @default.
- W4313350097 modified "2023-10-16" @default.
- W4313350097 title "Role of Axl receptor tyrosine kinase in the generation of intestinal γδ T cells (166.13)" @default.
- W4313350097 doi "https://doi.org/10.4049/jimmunol.186.supp.166.13" @default.
- W4313350097 hasPublicationYear "2011" @default.
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