Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313350136> ?p ?o ?g. }
Showing items 1 to 72 of
72
with 100 items per page.
- W4313350136 endingPage "155.9" @default.
- W4313350136 startingPage "155.9" @default.
- W4313350136 abstract "Abstract Almost all infectious diseases are initiated at mucosal surfaces, yet intramuscular or subcutaneous vaccination usually provides only minimal protection at sites of infection owing to suboptimal activation of the mucosal immune system. The neonatal Fc receptor (FcRn) mediates the transport of IgG across polarized epithelial cells lining mucosal surfaces. We mimicked this process by fusing a model antigen, herpes simplex virus type-2 (HSV-2) glycoprotein gD, to an IgG Fc fragment. Intranasal immunization, together with the adjuvant CpG, completely protected wild-type, but not FcRn knockout, mice after intravaginal challenge with virulent HSV-2 186. This immunization strategy induced efficient mucosal and systemic antibody, B- and T-cell immune responses, with stable protection for at least 6 months after vaccination in most of the immunized animals. The FcRn-IgG transcellular transport pathway may provide a general delivery route for subunit vaccines against many mucosal pathogens." @default.
- W4313350136 created "2023-01-06" @default.
- W4313350136 creator A5018199914 @default.
- W4313350136 creator A5021489790 @default.
- W4313350136 creator A5031024168 @default.
- W4313350136 creator A5036299368 @default.
- W4313350136 creator A5064212776 @default.
- W4313350136 date "2011-04-01" @default.
- W4313350136 modified "2023-10-16" @default.
- W4313350136 title "Efficient mucosal vaccination mediated by the neonatal Fc receptor (155.9)" @default.
- W4313350136 doi "https://doi.org/10.4049/jimmunol.186.supp.155.9" @default.
- W4313350136 hasPublicationYear "2011" @default.
- W4313350136 type Work @default.
- W4313350136 citedByCount "0" @default.
- W4313350136 crossrefType "journal-article" @default.
- W4313350136 hasAuthorship W4313350136A5018199914 @default.
- W4313350136 hasAuthorship W4313350136A5021489790 @default.
- W4313350136 hasAuthorship W4313350136A5031024168 @default.
- W4313350136 hasAuthorship W4313350136A5036299368 @default.
- W4313350136 hasAuthorship W4313350136A5064212776 @default.
- W4313350136 hasBestOaLocation W43133501362 @default.
- W4313350136 hasConcept C159047783 @default.
- W4313350136 hasConcept C159654299 @default.
- W4313350136 hasConcept C176285220 @default.
- W4313350136 hasConcept C203014093 @default.
- W4313350136 hasConcept C22070199 @default.
- W4313350136 hasConcept C2776946954 @default.
- W4313350136 hasConcept C2777863537 @default.
- W4313350136 hasConcept C2780649865 @default.
- W4313350136 hasConcept C2780801004 @default.
- W4313350136 hasConcept C2780898057 @default.
- W4313350136 hasConcept C71924100 @default.
- W4313350136 hasConcept C85663871 @default.
- W4313350136 hasConcept C86803240 @default.
- W4313350136 hasConcept C8891405 @default.
- W4313350136 hasConcept C95444343 @default.
- W4313350136 hasConceptScore W4313350136C159047783 @default.
- W4313350136 hasConceptScore W4313350136C159654299 @default.
- W4313350136 hasConceptScore W4313350136C176285220 @default.
- W4313350136 hasConceptScore W4313350136C203014093 @default.
- W4313350136 hasConceptScore W4313350136C22070199 @default.
- W4313350136 hasConceptScore W4313350136C2776946954 @default.
- W4313350136 hasConceptScore W4313350136C2777863537 @default.
- W4313350136 hasConceptScore W4313350136C2780649865 @default.
- W4313350136 hasConceptScore W4313350136C2780801004 @default.
- W4313350136 hasConceptScore W4313350136C2780898057 @default.
- W4313350136 hasConceptScore W4313350136C71924100 @default.
- W4313350136 hasConceptScore W4313350136C85663871 @default.
- W4313350136 hasConceptScore W4313350136C86803240 @default.
- W4313350136 hasConceptScore W4313350136C8891405 @default.
- W4313350136 hasConceptScore W4313350136C95444343 @default.
- W4313350136 hasIssue "1_Supplement" @default.
- W4313350136 hasLocation W43133501361 @default.
- W4313350136 hasLocation W43133501362 @default.
- W4313350136 hasOpenAccess W4313350136 @default.
- W4313350136 hasPrimaryLocation W43133501361 @default.
- W4313350136 hasRelatedWork W1815610272 @default.
- W4313350136 hasRelatedWork W1968196611 @default.
- W4313350136 hasRelatedWork W2014021736 @default.
- W4313350136 hasRelatedWork W2015201228 @default.
- W4313350136 hasRelatedWork W2073312739 @default.
- W4313350136 hasRelatedWork W2171475287 @default.
- W4313350136 hasRelatedWork W2205292570 @default.
- W4313350136 hasRelatedWork W2736540239 @default.
- W4313350136 hasRelatedWork W2772568294 @default.
- W4313350136 hasRelatedWork W1840551154 @default.
- W4313350136 hasVolume "186" @default.
- W4313350136 isParatext "false" @default.
- W4313350136 isRetracted "false" @default.
- W4313350136 workType "article" @default.