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- W4313350149 abstract "Abstract Differentiation, distribution and immune regulation of human IL-22-producing T cells in infections remain unknown.We demonstrated that M. tuberculosis infection resulted in apparent increases in numbers of T cells capable of producing IL-22 de novo without in vitro Ag stimulation, and drove distribution of these cells more dramatically in lungs than in blood and lymphoid tissues. Consistently, IL-22-producing T cells were visualized in situ in lung tuberculosis (TB) granulomas by confocal microscopy and immunohistochemistry, indicating that mature IL-22-producing T cells were present in TB granuloma. Surprisingly, phosphoantigen HMBPP activation of Vγ2Vδ2 T cells down-regulated the capability of T cells to produce IL-22 de novo. Up-regulation of IFNγ-producing Vγ2Vδ2 T effector cells after HMBPP stimulation coincided with the down-regulated capacity of these T cells to produce IL-22 de novo. Importantly, anti-IFNγ neutralizing Ab treatment reversed the HMBPP-mediated down-regulation effect on IL-22-producing T cells, suggesting that Vγ2Vδ2 T-cell-driven IFNγ-networking function was the mechanism underlying the HMBPP-mediated down-regulation of the capability of T cells to produce IL-22. These novel findings raise the possibility to ultimately investigate function of IL-22 producing T cells and to target Vγ2Vδ2 T cells for balancing potentially-hyper-activating IL-22-producing T cells in severe TB." @default.
- W4313350149 created "2023-01-06" @default.
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- W4313350149 date "2010-04-01" @default.
- W4313350149 modified "2023-09-23" @default.
- W4313350149 title "Differentiation, distribution and γδ T cell-driven regulation of IL-22-producing T cells in tuberculosis (45.21)" @default.
- W4313350149 doi "https://doi.org/10.4049/jimmunol.184.supp.45.21" @default.
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