Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313351379> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W4313351379 endingPage "133.9" @default.
- W4313351379 startingPage "133.9" @default.
- W4313351379 abstract "Abstract Dissecting the mechanisms that support autoantibody production is essential to our understanding of autoimmune diseases such as lupus. Recent work from our laboratory has shown that regulatory T cells (Tregs) play a key role in suppressing autoantibody production by helping to maintain B cell anergy. Our long-term goal is to understand how Tregs regulate B cell anergy. Our studies indicate that helper T cells play a key role as an intermediate between Treg and anergic B cells. Specifically, the absence of Tregs rapidly (within 4 days) drives the expansion of CD4+GL7+ helper T cells. This gross population can be further divided into 2 populations: germinal center follicular T cells (GC-TFH) and a novel non-TFH subset termed TAN cells. These GL7+ helper T cell subsets deliver potent signals to naïve and anergic B cells, inducing significant antibody production from both populations. Recent studies have begun to identify the signals that drive the expansion of GC-TFH and TAN cells in the absence of Tregs. We have shown that treatment of Treg-deficient mice with an agonistic anti-CD137 antibody reduces the expansion of CD4+GL7+ helper T cells (both GC-TFH and TAN cells). This treatment also reduced the expansion of class-switched B cells and abolished autoantibody production. Collectively, our studies indicate that CD137 signaling plays a key role in the expansion of pathogenic helper T cell subsets that support autoimmunity in the absence of Tregs." @default.
- W4313351379 created "2023-01-06" @default.
- W4313351379 creator A5010828416 @default.
- W4313351379 creator A5029770503 @default.
- W4313351379 creator A5083790713 @default.
- W4313351379 date "2013-05-01" @default.
- W4313351379 modified "2023-10-14" @default.
- W4313351379 title "Regulation of pathogenic GL7-expressing helper T cells by Tregs and CD137 (P4111)" @default.
- W4313351379 doi "https://doi.org/10.4049/jimmunol.190.supp.133.9" @default.
- W4313351379 hasPublicationYear "2013" @default.
- W4313351379 type Work @default.
- W4313351379 citedByCount "0" @default.
- W4313351379 crossrefType "journal-article" @default.
- W4313351379 hasAuthorship W4313351379A5010828416 @default.
- W4313351379 hasAuthorship W4313351379A5029770503 @default.
- W4313351379 hasAuthorship W4313351379A5083790713 @default.
- W4313351379 hasConcept C137756551 @default.
- W4313351379 hasConcept C154317977 @default.
- W4313351379 hasConcept C159654299 @default.
- W4313351379 hasConcept C163764329 @default.
- W4313351379 hasConcept C202751555 @default.
- W4313351379 hasConcept C203014093 @default.
- W4313351379 hasConcept C2776090121 @default.
- W4313351379 hasConcept C2778453870 @default.
- W4313351379 hasConcept C2780130043 @default.
- W4313351379 hasConcept C2780249625 @default.
- W4313351379 hasConcept C2908647359 @default.
- W4313351379 hasConcept C39347974 @default.
- W4313351379 hasConcept C542903549 @default.
- W4313351379 hasConcept C54355233 @default.
- W4313351379 hasConcept C71924100 @default.
- W4313351379 hasConcept C86803240 @default.
- W4313351379 hasConcept C8891405 @default.
- W4313351379 hasConcept C95444343 @default.
- W4313351379 hasConcept C96926380 @default.
- W4313351379 hasConcept C99454951 @default.
- W4313351379 hasConceptScore W4313351379C137756551 @default.
- W4313351379 hasConceptScore W4313351379C154317977 @default.
- W4313351379 hasConceptScore W4313351379C159654299 @default.
- W4313351379 hasConceptScore W4313351379C163764329 @default.
- W4313351379 hasConceptScore W4313351379C202751555 @default.
- W4313351379 hasConceptScore W4313351379C203014093 @default.
- W4313351379 hasConceptScore W4313351379C2776090121 @default.
- W4313351379 hasConceptScore W4313351379C2778453870 @default.
- W4313351379 hasConceptScore W4313351379C2780130043 @default.
- W4313351379 hasConceptScore W4313351379C2780249625 @default.
- W4313351379 hasConceptScore W4313351379C2908647359 @default.
- W4313351379 hasConceptScore W4313351379C39347974 @default.
- W4313351379 hasConceptScore W4313351379C542903549 @default.
- W4313351379 hasConceptScore W4313351379C54355233 @default.
- W4313351379 hasConceptScore W4313351379C71924100 @default.
- W4313351379 hasConceptScore W4313351379C86803240 @default.
- W4313351379 hasConceptScore W4313351379C8891405 @default.
- W4313351379 hasConceptScore W4313351379C95444343 @default.
- W4313351379 hasConceptScore W4313351379C96926380 @default.
- W4313351379 hasConceptScore W4313351379C99454951 @default.
- W4313351379 hasIssue "1_Supplement" @default.
- W4313351379 hasLocation W43133513791 @default.
- W4313351379 hasOpenAccess W4313351379 @default.
- W4313351379 hasPrimaryLocation W43133513791 @default.
- W4313351379 hasRelatedWork W1532617356 @default.
- W4313351379 hasRelatedWork W1663253897 @default.
- W4313351379 hasRelatedWork W1877571168 @default.
- W4313351379 hasRelatedWork W2017878096 @default.
- W4313351379 hasRelatedWork W2058746720 @default.
- W4313351379 hasRelatedWork W2059318379 @default.
- W4313351379 hasRelatedWork W2125680477 @default.
- W4313351379 hasRelatedWork W2518196601 @default.
- W4313351379 hasRelatedWork W3007729879 @default.
- W4313351379 hasRelatedWork W4206042128 @default.
- W4313351379 hasVolume "190" @default.
- W4313351379 isParatext "false" @default.
- W4313351379 isRetracted "false" @default.
- W4313351379 workType "article" @default.