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- W4313351396 abstract "Edema is an abnormally increased volume of interstitial fluid, and there are various causes of it. In particular, lymphedema due to lymphatic obstruction, which is closely related to cancer, will be reported, and the role of physical therapists in its treatment will be discussed. Some reports indicate that lymphedema occurs 15–20% of the time after breast cancer surgery and about 25% of the time after gynecologic cancer surgery. However details on the cause and duration of lymphedema are unknown. Treatment of lymphedema can be broadly classified into surgical and conservative treatments, and the effectiveness of each treatment method has been reported. Obesity has been widely reported to be involved in the development and exacerbation of lymphedema and may be a risk factor associated with the development of upper extremity lymphedema after breast cancer surgery. Clinically, it is known that fat cells proliferated and enlarged by obesity compress capillary lymph vessels and blood vessels, stagnating lymphatic movement and causing edema, but there are many causes for the development of edema. Adipocytokines, a group of protein factors secreted by white fat cells, have been reported to perform various functions. Among them, this time we focused on leptin. Comparison of leptin concentration between nonobese (10 ng/mL) and obese (100 ng/mL) subjects has shown that leptin concentration-dependent lymphatic vessel structure cannot be demonstrated and that tube formation is reduced. The suggestion that obesity may be involved in the development and exacerbation of lymphedema in vivo and in vitro indicates that physical therapists are experts in managing this disease by providing appropriate and effective physical therapy based on adequate evidence of exercise therapy for obesity." @default.
- W4313351396 created "2023-01-06" @default.
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- W4313351396 date "2022-01-01" @default.
- W4313351396 modified "2023-09-29" @default.
- W4313351396 title "Cancer-Related Lymphedema and Obesity" @default.
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- W4313351396 doi "https://doi.org/10.1007/978-981-19-6710-8_16" @default.
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