Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313351397> ?p ?o ?g. }
Showing items 1 to 64 of
64
with 100 items per page.
- W4313351397 endingPage "134.3" @default.
- W4313351397 startingPage "134.3" @default.
- W4313351397 abstract "Abstract Antigen presentation is essential for the initiation of a CD4 T cell immune response and is commonly associated with dendritic cells (DCs) presenting foreign antigen to CD4 T cells in the context of MHCII in lymphoid tissue. It is currently unclear as to which antigen presenting cells (APCs) are displaying antigen, and what the impact this has on CD4 T cells throughout a persistent bacterial infection. In this study, we use a murine model of typhoid fever by orally infecting resistant mice with a virulent strain of Salmonella typhimurium tagged with an immunogenic epitope called Eα52-68 peptide (pEα). This allows for the visualization of antigen presentation directly ex vivo at various times after infection through the use of the Y-Ae antibody that specifically recognizes the pEα:MHCII complex. We show that while DCs are the most prominent APC in the infected spleen and mesenteric lymph nodes early, macrophages seem to predominate in the liver. Surprisingly, we could still detect antigen presentation in the spleens of mice infected with pEα-tagged S. typhimurium as late as 120 days post infection. Additionally, interferon-γ responses from effector T cells could be detected directly ex vivo at this late time. These results demonstrate that that cells presenting antigen may differ greatly between persistently infected organs and paves the way to understanding what role this might have in regulating CD4 T cell responses during this type of infection." @default.
- W4313351397 created "2023-01-06" @default.
- W4313351397 creator A5017164396 @default.
- W4313351397 creator A5091202762 @default.
- W4313351397 date "2013-05-01" @default.
- W4313351397 modified "2023-09-27" @default.
- W4313351397 title "Tissue-specific antigen presentation to CD4 T cells during persistent <i>Salmonella</i> Typhimurium infection (P3300)" @default.
- W4313351397 doi "https://doi.org/10.4049/jimmunol.190.supp.134.3" @default.
- W4313351397 hasPublicationYear "2013" @default.
- W4313351397 type Work @default.
- W4313351397 citedByCount "0" @default.
- W4313351397 crossrefType "journal-article" @default.
- W4313351397 hasAuthorship W4313351397A5017164396 @default.
- W4313351397 hasAuthorship W4313351397A5091202762 @default.
- W4313351397 hasConcept C147483822 @default.
- W4313351397 hasConcept C154317977 @default.
- W4313351397 hasConcept C159047783 @default.
- W4313351397 hasConcept C195616568 @default.
- W4313351397 hasConcept C202751555 @default.
- W4313351397 hasConcept C203014093 @default.
- W4313351397 hasConcept C2776090121 @default.
- W4313351397 hasConcept C2779237934 @default.
- W4313351397 hasConcept C2780931953 @default.
- W4313351397 hasConcept C55493867 @default.
- W4313351397 hasConcept C67662055 @default.
- W4313351397 hasConcept C83464605 @default.
- W4313351397 hasConcept C86803240 @default.
- W4313351397 hasConcept C8891405 @default.
- W4313351397 hasConcept C89423630 @default.
- W4313351397 hasConceptScore W4313351397C147483822 @default.
- W4313351397 hasConceptScore W4313351397C154317977 @default.
- W4313351397 hasConceptScore W4313351397C159047783 @default.
- W4313351397 hasConceptScore W4313351397C195616568 @default.
- W4313351397 hasConceptScore W4313351397C202751555 @default.
- W4313351397 hasConceptScore W4313351397C203014093 @default.
- W4313351397 hasConceptScore W4313351397C2776090121 @default.
- W4313351397 hasConceptScore W4313351397C2779237934 @default.
- W4313351397 hasConceptScore W4313351397C2780931953 @default.
- W4313351397 hasConceptScore W4313351397C55493867 @default.
- W4313351397 hasConceptScore W4313351397C67662055 @default.
- W4313351397 hasConceptScore W4313351397C83464605 @default.
- W4313351397 hasConceptScore W4313351397C86803240 @default.
- W4313351397 hasConceptScore W4313351397C8891405 @default.
- W4313351397 hasConceptScore W4313351397C89423630 @default.
- W4313351397 hasIssue "1_Supplement" @default.
- W4313351397 hasLocation W43133513971 @default.
- W4313351397 hasOpenAccess W4313351397 @default.
- W4313351397 hasPrimaryLocation W43133513971 @default.
- W4313351397 hasRelatedWork W126206799 @default.
- W4313351397 hasRelatedWork W1568750314 @default.
- W4313351397 hasRelatedWork W1593392947 @default.
- W4313351397 hasRelatedWork W1965266909 @default.
- W4313351397 hasRelatedWork W1987197088 @default.
- W4313351397 hasRelatedWork W2033029996 @default.
- W4313351397 hasRelatedWork W2061429475 @default.
- W4313351397 hasRelatedWork W2076092609 @default.
- W4313351397 hasRelatedWork W2409421526 @default.
- W4313351397 hasRelatedWork W2895048412 @default.
- W4313351397 hasVolume "190" @default.
- W4313351397 isParatext "false" @default.
- W4313351397 isRetracted "false" @default.
- W4313351397 workType "article" @default.