Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313351408> ?p ?o ?g. }
Showing items 1 to 58 of
58
with 100 items per page.
- W4313351408 endingPage "188.9" @default.
- W4313351408 startingPage "188.9" @default.
- W4313351408 abstract "Abstract Development of natural regulatory T cells (nTregs) is requisite to maintain central tolerance. nTregs are believed to develop after receiving strong T cell receptor (TCR) signals during T cell maturation in the thymus. This notion comes from experimental systems wherein TCR transgenic T cells adopt the Treg fate only if their cognate antigen is present in the thymus during development. However, whether strong TCR signals drive nTreg development in a polyclonal setting and the specific signaling pathways downstream of the TCR necessary for nTreg development remain elusive. In this study, we selectively perturbed the lipid second messenger diacylglycerol (DAG), which is a critical component of TCR signaling. Using mice that lack DAG kinase-ζ (DGKζ), a negative regulator of DAG, we demonstrate that enhanced DAG signals result in a significant increase in nTreg development in a cell-autonomous manner. DGKζ-deficient T cells exhibited increased c-Rel and ERK signaling, suggesting that these downstream pathways may contribute to enhanced Treg development in DGKζ-deficient mice. Indeed, the absence of c-Rel almost completely abrogated the increase in Treg development observed in DGKζ-deficient mice. Moreover, inhibition of ERK also prevented Treg development in the absence of DGKζ. Our study shows that (1) nTreg development is enhanced by increased TCR signaling in a polyclonal setting and (2) DGKζ limits nTreg development by attenuating signals leading to ERK and c-Rel activation." @default.
- W4313351408 created "2023-01-06" @default.
- W4313351408 creator A5021316963 @default.
- W4313351408 creator A5037534938 @default.
- W4313351408 creator A5071121635 @default.
- W4313351408 date "2013-05-01" @default.
- W4313351408 modified "2023-10-17" @default.
- W4313351408 title "Diacylglycerol kinase-ζ limits natural regulatory T cell generation. (P1213)" @default.
- W4313351408 doi "https://doi.org/10.4049/jimmunol.190.supp.188.9" @default.
- W4313351408 hasPublicationYear "2013" @default.
- W4313351408 type Work @default.
- W4313351408 citedByCount "0" @default.
- W4313351408 crossrefType "journal-article" @default.
- W4313351408 hasAuthorship W4313351408A5021316963 @default.
- W4313351408 hasAuthorship W4313351408A5037534938 @default.
- W4313351408 hasAuthorship W4313351408A5071121635 @default.
- W4313351408 hasConcept C163235415 @default.
- W4313351408 hasConcept C19317047 @default.
- W4313351408 hasConcept C195794163 @default.
- W4313351408 hasConcept C203014093 @default.
- W4313351408 hasConcept C2776090121 @default.
- W4313351408 hasConcept C36020004 @default.
- W4313351408 hasConcept C57074206 @default.
- W4313351408 hasConcept C62478195 @default.
- W4313351408 hasConcept C86803240 @default.
- W4313351408 hasConcept C8891405 @default.
- W4313351408 hasConcept C95444343 @default.
- W4313351408 hasConceptScore W4313351408C163235415 @default.
- W4313351408 hasConceptScore W4313351408C19317047 @default.
- W4313351408 hasConceptScore W4313351408C195794163 @default.
- W4313351408 hasConceptScore W4313351408C203014093 @default.
- W4313351408 hasConceptScore W4313351408C2776090121 @default.
- W4313351408 hasConceptScore W4313351408C36020004 @default.
- W4313351408 hasConceptScore W4313351408C57074206 @default.
- W4313351408 hasConceptScore W4313351408C62478195 @default.
- W4313351408 hasConceptScore W4313351408C86803240 @default.
- W4313351408 hasConceptScore W4313351408C8891405 @default.
- W4313351408 hasConceptScore W4313351408C95444343 @default.
- W4313351408 hasIssue "1_Supplement" @default.
- W4313351408 hasLocation W43133514081 @default.
- W4313351408 hasOpenAccess W4313351408 @default.
- W4313351408 hasPrimaryLocation W43133514081 @default.
- W4313351408 hasRelatedWork W1864003662 @default.
- W4313351408 hasRelatedWork W1966940637 @default.
- W4313351408 hasRelatedWork W1988808374 @default.
- W4313351408 hasRelatedWork W2000423367 @default.
- W4313351408 hasRelatedWork W2015613048 @default.
- W4313351408 hasRelatedWork W2537799114 @default.
- W4313351408 hasRelatedWork W3032948099 @default.
- W4313351408 hasRelatedWork W4313344878 @default.
- W4313351408 hasRelatedWork W4313351408 @default.
- W4313351408 hasRelatedWork W47822334 @default.
- W4313351408 hasVolume "190" @default.
- W4313351408 isParatext "false" @default.
- W4313351408 isRetracted "false" @default.
- W4313351408 workType "article" @default.