Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313351410> ?p ?o ?g. }
Showing items 1 to 64 of
64
with 100 items per page.
- W4313351410 endingPage "127.1" @default.
- W4313351410 startingPage "127.1" @default.
- W4313351410 abstract "Abstract NGAL (lipocalin-2), a member of the lipocalin superfamily, is expressed by neutrophils, hepatocytes, and renal resident cells following inflammatory conditions, and is involved in innate immunity during infection. Previously, we found that NGAL worsens renal disease in nephrotoxic nephritis. However, its relevance to adaptive immunity has not been fully explored. To investigate a possible role for NGAL in autoreactive antibody responses in experimental lupus, we injected pristane into B6 (n=10) and NGAL-deficient B6 (NGAL-/-) (n=10) mice. Analyzing the levels of serum autoantibodies at 3 months post injection, we found that B6 NGAL-/- mice had significant increases in IgG2a and IgG2b anti-double stranded DNA antibodies. Similarly, the titers of IgG2a and IgG2b antibodies to single stranded DNA and histone were significantly increased in pristane challenged NGAL-/- mice as compared to NGAL sufficient mice. Furthermore, elevated serum anti-ribonucleoprotein antibodies were found in pristane treated NGAL-/- mice by immunoprecipitation. Although autoantibody titers in NGAL-/- mice were not increased at baseline, our results are consistent with the apoptotic defects and accumulation of lymphoid cells reported previously in these mice. We also found significant upregulation of IRF5, IP-10, CXCL13, CXCR5, CxCR3, PD-1, PD-L1, and activation induced cytidine deaminase (AID) in spleens of NGAL-/- mice compared to WT mice. In vitro, we found that pristane and other inflammatory mediators promoted NGAL secretion by splenocytes. In conclusion, NGAL deficiency accelerates the onset of anti-nuclear antibodies in pristane induced lupus, suggesting that NGAL may regulate the spontaneous or induced humoral autoimmunity." @default.
- W4313351410 created "2023-01-06" @default.
- W4313351410 creator A5027035176 @default.
- W4313351410 creator A5029479045 @default.
- W4313351410 creator A5036519472 @default.
- W4313351410 creator A5046223338 @default.
- W4313351410 creator A5046874707 @default.
- W4313351410 creator A5088498253 @default.
- W4313351410 date "2013-05-01" @default.
- W4313351410 modified "2023-10-01" @default.
- W4313351410 title "Neutrophil Gelatinase Associated Lipocalin (NGAL) regulates the onset of serum autoantibodies in pristane induced lupus (P4059)" @default.
- W4313351410 doi "https://doi.org/10.4049/jimmunol.190.supp.127.1" @default.
- W4313351410 hasPublicationYear "2013" @default.
- W4313351410 type Work @default.
- W4313351410 citedByCount "0" @default.
- W4313351410 crossrefType "journal-article" @default.
- W4313351410 hasAuthorship W4313351410A5027035176 @default.
- W4313351410 hasAuthorship W4313351410A5029479045 @default.
- W4313351410 hasAuthorship W4313351410A5036519472 @default.
- W4313351410 hasAuthorship W4313351410A5046223338 @default.
- W4313351410 hasAuthorship W4313351410A5046874707 @default.
- W4313351410 hasAuthorship W4313351410A5088498253 @default.
- W4313351410 hasConcept C126322002 @default.
- W4313351410 hasConcept C134018914 @default.
- W4313351410 hasConcept C159654299 @default.
- W4313351410 hasConcept C163764329 @default.
- W4313351410 hasConcept C20299238 @default.
- W4313351410 hasConcept C203014093 @default.
- W4313351410 hasConcept C2776912625 @default.
- W4313351410 hasConcept C2779134260 @default.
- W4313351410 hasConcept C2780130043 @default.
- W4313351410 hasConcept C71924100 @default.
- W4313351410 hasConcept C86803240 @default.
- W4313351410 hasConceptScore W4313351410C126322002 @default.
- W4313351410 hasConceptScore W4313351410C134018914 @default.
- W4313351410 hasConceptScore W4313351410C159654299 @default.
- W4313351410 hasConceptScore W4313351410C163764329 @default.
- W4313351410 hasConceptScore W4313351410C20299238 @default.
- W4313351410 hasConceptScore W4313351410C203014093 @default.
- W4313351410 hasConceptScore W4313351410C2776912625 @default.
- W4313351410 hasConceptScore W4313351410C2779134260 @default.
- W4313351410 hasConceptScore W4313351410C2780130043 @default.
- W4313351410 hasConceptScore W4313351410C71924100 @default.
- W4313351410 hasConceptScore W4313351410C86803240 @default.
- W4313351410 hasIssue "1_Supplement" @default.
- W4313351410 hasLocation W43133514101 @default.
- W4313351410 hasOpenAccess W4313351410 @default.
- W4313351410 hasPrimaryLocation W43133514101 @default.
- W4313351410 hasRelatedWork W110475813 @default.
- W4313351410 hasRelatedWork W1484311423 @default.
- W4313351410 hasRelatedWork W2026476849 @default.
- W4313351410 hasRelatedWork W2042848281 @default.
- W4313351410 hasRelatedWork W2065920961 @default.
- W4313351410 hasRelatedWork W2083730628 @default.
- W4313351410 hasRelatedWork W2092313476 @default.
- W4313351410 hasRelatedWork W2412943649 @default.
- W4313351410 hasRelatedWork W811736521 @default.
- W4313351410 hasRelatedWork W1564372652 @default.
- W4313351410 hasVolume "190" @default.
- W4313351410 isParatext "false" @default.
- W4313351410 isRetracted "false" @default.
- W4313351410 workType "article" @default.