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- W4313351427 endingPage "132.1" @default.
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- W4313351427 abstract "Abstract N glycolylated (NeuGc) gangliosides are not normal components of the cytoplasmic membrane in humans, but their expression has been demonstrated in several human malignant tumors. We demonstrated in healthy donors the existence of naturally occurring antibodies that bind NeuGc containing gangliosides and are able to kill NeuGcGM3 expressing tumor cells. Both the levels and frequency of these anti NeuGcGM3 antibodies decreased with age. Interestingly, this reactivity was almost absent in the sera of non-small cell lung cancer patients. 1E10 is an anti-idiotype mAb specific for an antibody which reacts to NeuGc gangliosides. A phase 2 multicenter, controlled, randomized, double blind clinical trial was conducted to evaluate the effect of aluminum hydroxide precipitated 1E10 vaccine in the overall survival of patients with advanced NSCLC who have completed onco specific treatment. The clinical results of this study showed a significant increase in the overall survival, according to both the intent to treat and the per protocol analysis, as well as in the long term survival rates, for the 1E10 treated patients in comparison with the placebo group. The immunological studies performed showed that the patients that elicited anti NeuGcGM3 antibodies with cytotoxic capacity had a statistically significant increase in the survival times." @default.
- W4313351427 created "2023-01-06" @default.
- W4313351427 creator A5063328585 @default.
- W4313351427 date "2013-05-01" @default.
- W4313351427 modified "2023-09-26" @default.
- W4313351427 title "Induction of cytotoxic anti-tumor antibodies against N Glycolyl containing gangliosides through idiotypic vaccination: clinical data (P2022)" @default.
- W4313351427 doi "https://doi.org/10.4049/jimmunol.190.supp.132.1" @default.
- W4313351427 hasPublicationYear "2013" @default.
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