Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313351439> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W4313351439 endingPage "124.3" @default.
- W4313351439 startingPage "124.3" @default.
- W4313351439 abstract "Abstract CD4+ T cells play a major role in the modulation of immune responses at the gastric mucosa during Helicobacter pylori infection. The relative contributions of CD4+ T cell subsets to gastritis and control of H. pylori colonization and clearance are not completely understood. Expression of IL-21, which is produced by a number of T cell subsets, increases during H. pylori infection. To elucidate the mechanisms of action of IL-21 in effector and regulatory CD4+ T cells during H. pylori infection, we combined computational modeling of CD4+ T cell differentiation and in vivo challenge studies in mice. Our computational modeling predicted activated production of IFNγ and IL-17 by IL-21, and the expression of T-bet, RORγt and phosphorylation of STAT3. To investigate the role of IL-21 in vivo, we infected IL-21-/- and wild-type mice with H. pylori SS1, and assessed colonization, gastric inflammation, cellular infiltration and cytokine profiles in the gastric mucosa. During chronic infection, IL-21-/- mice had higher H. pylori colonization, less gastritis and reduced expression of inflammatory cytokines and chemokines. Moreover, H. pylori infected IL-21-/- mice had reduced levels of CD4+ T cell specific RORγt and T-bet when compared to infected wild-type mice. Our results indicate that IL-21 contributes to the control of infection and severity of gastritis, suggesting a role for induction of gastritis in response to H. pylori through activation of both Th17 and Th1 effector responses." @default.
- W4313351439 created "2023-01-06" @default.
- W4313351439 creator A5011038224 @default.
- W4313351439 creator A5022404056 @default.
- W4313351439 creator A5036231550 @default.
- W4313351439 creator A5049202342 @default.
- W4313351439 creator A5049284265 @default.
- W4313351439 creator A5058888863 @default.
- W4313351439 creator A5061544889 @default.
- W4313351439 creator A5087379114 @default.
- W4313351439 date "2013-05-01" @default.
- W4313351439 modified "2023-10-17" @default.
- W4313351439 title "IL-21 is required for maintaining mucosal Th1 and Th17 responses during <i>Helicobacter pylori</i> infection (P3184)" @default.
- W4313351439 doi "https://doi.org/10.4049/jimmunol.190.supp.124.3" @default.
- W4313351439 hasPublicationYear "2013" @default.
- W4313351439 type Work @default.
- W4313351439 citedByCount "0" @default.
- W4313351439 crossrefType "journal-article" @default.
- W4313351439 hasAuthorship W4313351439A5011038224 @default.
- W4313351439 hasAuthorship W4313351439A5022404056 @default.
- W4313351439 hasAuthorship W4313351439A5036231550 @default.
- W4313351439 hasAuthorship W4313351439A5049202342 @default.
- W4313351439 hasAuthorship W4313351439A5049284265 @default.
- W4313351439 hasAuthorship W4313351439A5058888863 @default.
- W4313351439 hasAuthorship W4313351439A5061544889 @default.
- W4313351439 hasAuthorship W4313351439A5087379114 @default.
- W4313351439 hasConcept C13373296 @default.
- W4313351439 hasConcept C150903083 @default.
- W4313351439 hasConcept C203014093 @default.
- W4313351439 hasConcept C207001950 @default.
- W4313351439 hasConcept C2776090121 @default.
- W4313351439 hasConcept C2776409635 @default.
- W4313351439 hasConcept C2776914184 @default.
- W4313351439 hasConcept C2778677798 @default.
- W4313351439 hasConcept C2778690821 @default.
- W4313351439 hasConcept C2779422922 @default.
- W4313351439 hasConcept C2779727006 @default.
- W4313351439 hasConcept C2780832600 @default.
- W4313351439 hasConcept C2781443798 @default.
- W4313351439 hasConcept C47348012 @default.
- W4313351439 hasConcept C54355233 @default.
- W4313351439 hasConcept C55493867 @default.
- W4313351439 hasConcept C74737994 @default.
- W4313351439 hasConcept C86803240 @default.
- W4313351439 hasConcept C8891405 @default.
- W4313351439 hasConceptScore W4313351439C13373296 @default.
- W4313351439 hasConceptScore W4313351439C150903083 @default.
- W4313351439 hasConceptScore W4313351439C203014093 @default.
- W4313351439 hasConceptScore W4313351439C207001950 @default.
- W4313351439 hasConceptScore W4313351439C2776090121 @default.
- W4313351439 hasConceptScore W4313351439C2776409635 @default.
- W4313351439 hasConceptScore W4313351439C2776914184 @default.
- W4313351439 hasConceptScore W4313351439C2778677798 @default.
- W4313351439 hasConceptScore W4313351439C2778690821 @default.
- W4313351439 hasConceptScore W4313351439C2779422922 @default.
- W4313351439 hasConceptScore W4313351439C2779727006 @default.
- W4313351439 hasConceptScore W4313351439C2780832600 @default.
- W4313351439 hasConceptScore W4313351439C2781443798 @default.
- W4313351439 hasConceptScore W4313351439C47348012 @default.
- W4313351439 hasConceptScore W4313351439C54355233 @default.
- W4313351439 hasConceptScore W4313351439C55493867 @default.
- W4313351439 hasConceptScore W4313351439C74737994 @default.
- W4313351439 hasConceptScore W4313351439C86803240 @default.
- W4313351439 hasConceptScore W4313351439C8891405 @default.
- W4313351439 hasIssue "1_Supplement" @default.
- W4313351439 hasLocation W43133514391 @default.
- W4313351439 hasOpenAccess W4313351439 @default.
- W4313351439 hasPrimaryLocation W43133514391 @default.
- W4313351439 hasRelatedWork W2005666125 @default.
- W4313351439 hasRelatedWork W2114038508 @default.
- W4313351439 hasRelatedWork W2130030508 @default.
- W4313351439 hasRelatedWork W2396120344 @default.
- W4313351439 hasRelatedWork W25059082 @default.
- W4313351439 hasRelatedWork W2794223676 @default.
- W4313351439 hasRelatedWork W3022601493 @default.
- W4313351439 hasRelatedWork W3087626241 @default.
- W4313351439 hasRelatedWork W4313351439 @default.
- W4313351439 hasRelatedWork W2182591125 @default.
- W4313351439 hasVolume "190" @default.
- W4313351439 isParatext "false" @default.
- W4313351439 isRetracted "false" @default.
- W4313351439 workType "article" @default.