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- W4313351454 abstract "Abstract Expression of CD19 on B cells modulates B cell receptor signaling threshold. Reduced CD19 expression has been observed in some human patients with common variable immune deficiency (CVID), a disease which is characterized by low production of mature B cells with a paradoxical increase in auto-reactivity. Development of the B cell repertoire in the absence of CD19 expression has not been well characterized. We previously showed that the B cell repertoire is controlled by the sequence characteristics of the complementary determining region heavy chain (CDR-H3). We sought to examine the CDR-H3 repertoire in mice lacking CD19 expression, using our novel bioinformatics system, to test whether its absence can affect the control of B cell repertoire content, yielding altered development and auto reactive antibody production. We analyzed the CDR-H3 based on its length, reading frame usage and average hydrophobicity of its amino acid contents. Follicular B cells lacking CD19 expression were found to express an increase in the use of both highly charged and highly hydrophobic CDR-H3 sequences, sequences that are normally excluded from the follicles. Conversely, when compared to C57BL/6 controls, hydrophobic CDR-H3s were suppressed among marginal zone B cells. These findings indicate a loss of normal repertoire control in the absence of CD19, which may help explain why CD19 deficient patients have altered responses to self and non-self antigens." @default.
- W4313351454 created "2023-01-06" @default.
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- W4313351454 date "2013-05-01" @default.
- W4313351454 modified "2023-09-25" @default.
- W4313351454 title "Loss of CD19 expression alters the CDR-H3 content of marginal zone and follicular B cells, changing the composition of the immunoglobulin antigen receptor repertoire (P3022)" @default.
- W4313351454 doi "https://doi.org/10.4049/jimmunol.190.supp.114.12" @default.
- W4313351454 hasPublicationYear "2013" @default.
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