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- W4313351483 startingPage "41.17" @default.
- W4313351483 abstract "Abstract Tuberculosis (TB) is one of the most prevalent global health crises in the world today and is caused by the bacterium Mycobacterium Tuberculosis (Mtb). While CD4+ T cells are known to be critical in the protective response against Mtb, the importance of CD8+T cell responses are gaining attention. The current vaccine BCG has limited and variable efficacy. BCG induces a strong CD4, but weak CD8+ T cell response. Targeting epitopes to specific dendritic cell receptors is an efficient way to induce T cell immunity. We created recombinant antibodies that recognize the pro-phagocytic receptor DEC205 (CD205), the co-stimulatory molecule CD40, and the phagocytic/activating Fc receptors 2/3 (FcR II/III) (CD16/32). Fused to the Fc portion of the antibodies is an Mtb immunodominant peptide, as well as a CD8+ T cell epitope. Individually, or in combination, these antibodies induce robust CD4+, antigen specific immune response in vivo. Here, we report that these DC receptor-specific recombinant antibodies cross present and cross prime antigen-specific CD8+ T cells. These responses were measured by activation and proliferation both in vitro and in vivo studies. These recombinant antibodies give us a new tool to understand how DC surface receptors influence the processing and cross-presentation of antigens to T cells. In future studies, we will use these recombinant antibodies in combination with BCG in a murine mycobacterium infection model to induce protective immunity against Mtb." @default.
- W4313351483 created "2023-01-06" @default.
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- W4313351483 date "2013-05-01" @default.
- W4313351483 modified "2023-10-16" @default.
- W4313351483 title "Crosspresentation with epitope-tagged antibodies targeted to different molecules on the dendritic cell surface (P5032)" @default.
- W4313351483 doi "https://doi.org/10.4049/jimmunol.190.supp.41.17" @default.
- W4313351483 hasPublicationYear "2013" @default.
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