Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313351566> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W4313351566 endingPage "127.10" @default.
- W4313351566 startingPage "127.10" @default.
- W4313351566 abstract "Abstract Multiple sclerosis (MS) is an autoimmune disease that is mediated by myelin-reactive T cells resulting in CNS demyelination. Mice that are transgenic for a myelin proteolipid protein (PLP)-specific T cell receptor (TCR) spontaneously develop experimental autoimmune encephalomyelitis (EAE), the animal model of MS. MyD88 is the key adaptor protein in Toll-like receptor (TLR), IL-1R and IL-18R signaling, resulting in the activation of innate immune cells, including DCs. Although, MyD88-signaling is critical for T cell responses against microbial agents, it is unknown whether it is required for priming of myelin-reactive T cells in spontaneous EAE or MS. Here, we investigated the requirement of MyD88-signaling for the pathogenesis of spontaneous EAE in PLP TCR transgenic mice that genetically lacked MyD88. We demonstrate that MyD88 is dispensable for the development of spontaneous EAE and autoimmune demyelination in these mice. MyD88-independent EAE was associated with activated DCs that showed superior ability to promote PLP-specific Th1 and Th17 responses in vitro compared to DCs from healthy counterparts. In addition, we provide evidence indicating that the MyD88-independent TRIF signaling pathway was induced in EAE-diseased mice. Taken together, our data suggest that MyD88-independent innate immune signaling critically contributes to priming of myelin-reactive T cells and initiation of spontaneous EAE in our MS model." @default.
- W4313351566 created "2023-01-06" @default.
- W4313351566 creator A5006046496 @default.
- W4313351566 creator A5010388051 @default.
- W4313351566 creator A5025049586 @default.
- W4313351566 creator A5028724424 @default.
- W4313351566 creator A5046843439 @default.
- W4313351566 creator A5053256078 @default.
- W4313351566 creator A5065112517 @default.
- W4313351566 date "2013-05-01" @default.
- W4313351566 modified "2023-10-15" @default.
- W4313351566 title "MyD88, a central innate immune adaptor, is dispensable for spontaneous autoimmune demyelination in a mouse model of multiple sclerosis (P4077)" @default.
- W4313351566 doi "https://doi.org/10.4049/jimmunol.190.supp.127.10" @default.
- W4313351566 hasPublicationYear "2013" @default.
- W4313351566 type Work @default.
- W4313351566 citedByCount "0" @default.
- W4313351566 crossrefType "journal-article" @default.
- W4313351566 hasAuthorship W4313351566A5006046496 @default.
- W4313351566 hasAuthorship W4313351566A5010388051 @default.
- W4313351566 hasAuthorship W4313351566A5025049586 @default.
- W4313351566 hasAuthorship W4313351566A5028724424 @default.
- W4313351566 hasAuthorship W4313351566A5046843439 @default.
- W4313351566 hasAuthorship W4313351566A5053256078 @default.
- W4313351566 hasAuthorship W4313351566A5065112517 @default.
- W4313351566 hasConcept C100701293 @default.
- W4313351566 hasConcept C136449434 @default.
- W4313351566 hasConcept C169760540 @default.
- W4313351566 hasConcept C183786373 @default.
- W4313351566 hasConcept C19317047 @default.
- W4313351566 hasConcept C193419808 @default.
- W4313351566 hasConcept C203014093 @default.
- W4313351566 hasConcept C2776090121 @default.
- W4313351566 hasConcept C2776709828 @default.
- W4313351566 hasConcept C2777426553 @default.
- W4313351566 hasConcept C2778486448 @default.
- W4313351566 hasConcept C2778609137 @default.
- W4313351566 hasConcept C2780640218 @default.
- W4313351566 hasConcept C2780876595 @default.
- W4313351566 hasConcept C43929388 @default.
- W4313351566 hasConcept C529278444 @default.
- W4313351566 hasConcept C59822182 @default.
- W4313351566 hasConcept C62478195 @default.
- W4313351566 hasConcept C81444415 @default.
- W4313351566 hasConcept C86803240 @default.
- W4313351566 hasConcept C8891405 @default.
- W4313351566 hasConcept C95444343 @default.
- W4313351566 hasConceptScore W4313351566C100701293 @default.
- W4313351566 hasConceptScore W4313351566C136449434 @default.
- W4313351566 hasConceptScore W4313351566C169760540 @default.
- W4313351566 hasConceptScore W4313351566C183786373 @default.
- W4313351566 hasConceptScore W4313351566C19317047 @default.
- W4313351566 hasConceptScore W4313351566C193419808 @default.
- W4313351566 hasConceptScore W4313351566C203014093 @default.
- W4313351566 hasConceptScore W4313351566C2776090121 @default.
- W4313351566 hasConceptScore W4313351566C2776709828 @default.
- W4313351566 hasConceptScore W4313351566C2777426553 @default.
- W4313351566 hasConceptScore W4313351566C2778486448 @default.
- W4313351566 hasConceptScore W4313351566C2778609137 @default.
- W4313351566 hasConceptScore W4313351566C2780640218 @default.
- W4313351566 hasConceptScore W4313351566C2780876595 @default.
- W4313351566 hasConceptScore W4313351566C43929388 @default.
- W4313351566 hasConceptScore W4313351566C529278444 @default.
- W4313351566 hasConceptScore W4313351566C59822182 @default.
- W4313351566 hasConceptScore W4313351566C62478195 @default.
- W4313351566 hasConceptScore W4313351566C81444415 @default.
- W4313351566 hasConceptScore W4313351566C86803240 @default.
- W4313351566 hasConceptScore W4313351566C8891405 @default.
- W4313351566 hasConceptScore W4313351566C95444343 @default.
- W4313351566 hasIssue "1_Supplement" @default.
- W4313351566 hasLocation W43133515661 @default.
- W4313351566 hasOpenAccess W4313351566 @default.
- W4313351566 hasPrimaryLocation W43133515661 @default.
- W4313351566 hasRelatedWork W1999097527 @default.
- W4313351566 hasRelatedWork W2093852189 @default.
- W4313351566 hasRelatedWork W2145019698 @default.
- W4313351566 hasRelatedWork W2166551342 @default.
- W4313351566 hasRelatedWork W2363589151 @default.
- W4313351566 hasRelatedWork W2391862782 @default.
- W4313351566 hasRelatedWork W3117050850 @default.
- W4313351566 hasRelatedWork W4242262260 @default.
- W4313351566 hasRelatedWork W4313351566 @default.
- W4313351566 hasRelatedWork W82344848 @default.
- W4313351566 hasVolume "190" @default.
- W4313351566 isParatext "false" @default.
- W4313351566 isRetracted "false" @default.
- W4313351566 workType "article" @default.