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- W4313351608 startingPage "125.10" @default.
- W4313351608 abstract "Abstract Host cell death is critical to the fate of bacterial infection, to host innate immune responses, and to disease outcome. In this study we found that Shigella organisms could invade the terminal ileum of the small intestine in mice by 1 hour of early phase infection and be rapidly cleared within 24 hours even though Shigellae are considered human-specific pathogens. Early phase events after oral infection showed epithelial shedding, degranulation of Paneth cells, and cell death in the intestine without any signs of inflammation. Dead products including DNA and intracellular organelles trapped Shigellae and damaged tissue rapidly recovered within a day. These acute responses occurred with both human-specific pathogens such as Escherichia coli and with such murine pathogens as Salmonella typhimurium. Of interest, human intestine also shared this intrinsic defense. Here we propose a general intrinsic mechanism that repels the initial introduction of entero-pathogenic bacteria by sacrificing host cells." @default.
- W4313351608 created "2023-01-06" @default.
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- W4313351608 date "2013-05-01" @default.
- W4313351608 modified "2023-10-18" @default.
- W4313351608 title "Acute non-inflammatory epithelial death plays a role in intrinsic defense against enteric bacteria (P3064)" @default.
- W4313351608 doi "https://doi.org/10.4049/jimmunol.190.supp.125.10" @default.
- W4313351608 hasPublicationYear "2013" @default.
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