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- W4313351612 abstract "Abstract Secretory IgA (SIgA) Abs play an important role in the protection of mucosal surfaces including the respiratory tract. Several bacterial toxin and derivatives were shown to act as adjuvants and promote SIgA responses to co-administered antigens, but little is known about potential of plant toxins and derivatives to induce SIgA Abs. We found that chemically inactivated ricin toxoid (RT) increases the frequencies of CD11b+phospho-p65 NF-κB+ cells in nasopharyngeal-associated lymphoid tissues (NALT), an effect associated with increased expression of CD40 molecules on CD11b+ macrophages and enhanced pro-inflammatory cytokine responses. Three hours after intranasal administration of RT in vivo, NALT tissues showed a significant increase in the percentage of B220+ cells, which appeared to undergo rapid proliferation. When nasally co-administered with an unrelated antigen, RT induced broad antigen-specific T helper cell-cytokine responses and promoted antigen-specific SIgA Abs. This adjuvant effect of RT was altered in NALP3 KO mice, which exhibited lower number of B cells in NALT after intranasal administration of RT. Furthermore, antigen-specific T cell and B cell responses, as well as antigen-specific SIgA Ab responses were diminished significantly in NALP3 KO mice. Our results show that the plant toxin derivative RT is a mucosal adjuvant, which promotes SIgA via B cell-recruitment and activation in NALT tissues, and that NALP3 is a key regulator of this activity." @default.
- W4313351612 created "2023-01-06" @default.
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- W4313351612 date "2013-05-01" @default.
- W4313351612 modified "2023-09-30" @default.
- W4313351612 title "NALP3 regulates NALT B220+ cell-responses to ricin toxoid and induction of secretory IgA Abs (P3194)" @default.
- W4313351612 doi "https://doi.org/10.4049/jimmunol.190.supp.124.8" @default.
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