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- W4313351622 abstract "Abstract Mucosal surfaces are tightly regulated immune microenvironments with unique anatomical structures, profiles of cells and cytokines. These aspects, coupled with infection derived inflammatory signals, can differentially modulate downstream immunological responses. Thymic stromal lymphopoietin (TSLP) is a cytokine expressed in mucosal surfaces where its role in CD4 T cell immunity has been well studied. However, whether TSLP directly affects anti-viral mucosal CD8 T cell responses is less understood. Here, we show that influenza induces TSLP production in a lung epithelial cell line and infected mice. To test the direct role of TSLP on mucosal CD8 T cell responses we used a competitive adoptive transfer system where equal numbers of OVA-specific OT-I and TSLP receptor deficient OT-I cells are co-transferred into recipient mice infected with influenza expressing OVA. We found that TSLPR-/- OT-I CD8 T cells proliferate less early post infection (pi) and have decreased accumulation in the respiratory tract both at days 8 and 50pi. Interestingly, the lack of TSLP signaling imparted a higher level of CD62L expression on TSLPR-/- OT-I memory cells. Together these data suggest that TSLP signaling may directly drive the expansion and development of CD8 effector phenotypes while concomitantly limiting long term responses. Thus, TSLP participates in the regulation of immune responses in the respiratory tract and modulation of TSLP levels may promote long term immunity at mucosal sites." @default.
- W4313351622 created "2023-01-06" @default.
- W4313351622 creator A5045691206 @default.
- W4313351622 creator A5088475100 @default.
- W4313351622 date "2013-05-01" @default.
- W4313351622 modified "2023-09-30" @default.
- W4313351622 title "Thymic stromal lymphopoietin directly influences the respiratory CD8 T cell response to influenza virus infection. (P3230)" @default.
- W4313351622 doi "https://doi.org/10.4049/jimmunol.190.supp.124.26" @default.
- W4313351622 hasPublicationYear "2013" @default.
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