Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313351624> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W4313351624 endingPage "126.2" @default.
- W4313351624 startingPage "126.2" @default.
- W4313351624 abstract "Abstract Adeno-associated (AAV) vectors are being assessed for gene replacement therapy in humans. Proteins encoded by the vector transgene are potentially foreign. Strategies to temper destructive immune responses may be required to achieve a therapeutic effect, particularly in diseases like Duchenne Muscular Dystrophy where the defective gene to be replaced has a large frame-shifting deletion. Here we studied the impact of immunity on expression of enhanced green fluorescent protein (eGFP) in AAV-transduced skeletal muscle of rhesus macaques. Antibodies to eGFP developed rapidly after AAV vector delivery to the tibialis anterior muscle. Cellular immunity was variable. In some animals, strong CD4+ helper and CD8+ cytotoxic T cells were detected in blood 2 weeks after vector administration. In others, low frequency responses were not detected until week 5-6. Regardless of the pace of the response, eGFP was cleared or substantially diminished in muscle after week 6. Antibody-mediated depletion of CD4+ T cells before AAV vector treatment delayed antibody and CD8+ T cell immunity and facilitated robust expression of eGFP persisted through day 42. Some positive muscle fibers were still visible at month 10, an unexpected finding that suggested an inability to sustain destructive cellular immune responses initially primed without CD4+ T cell help. The capacity for recall of eGFP-CD8+ T cell responses upon administration of a serologically distinct AAV vector is now being assessed." @default.
- W4313351624 created "2023-01-06" @default.
- W4313351624 creator A5004265952 @default.
- W4313351624 creator A5010054582 @default.
- W4313351624 creator A5015187893 @default.
- W4313351624 creator A5023347371 @default.
- W4313351624 creator A5027135525 @default.
- W4313351624 creator A5035813419 @default.
- W4313351624 creator A5081143834 @default.
- W4313351624 date "2013-05-01" @default.
- W4313351624 modified "2023-10-17" @default.
- W4313351624 title "CD4+ helper T cells and immunity to therapeutic proteins in gene therapy (P4431)" @default.
- W4313351624 doi "https://doi.org/10.4049/jimmunol.190.supp.126.2" @default.
- W4313351624 hasPublicationYear "2013" @default.
- W4313351624 type Work @default.
- W4313351624 citedByCount "0" @default.
- W4313351624 crossrefType "journal-article" @default.
- W4313351624 hasAuthorship W4313351624A5004265952 @default.
- W4313351624 hasAuthorship W4313351624A5010054582 @default.
- W4313351624 hasAuthorship W4313351624A5015187893 @default.
- W4313351624 hasAuthorship W4313351624A5023347371 @default.
- W4313351624 hasAuthorship W4313351624A5027135525 @default.
- W4313351624 hasAuthorship W4313351624A5035813419 @default.
- W4313351624 hasAuthorship W4313351624A5081143834 @default.
- W4313351624 hasConcept C102230213 @default.
- W4313351624 hasConcept C104317684 @default.
- W4313351624 hasConcept C111599444 @default.
- W4313351624 hasConcept C154317977 @default.
- W4313351624 hasConcept C159047783 @default.
- W4313351624 hasConcept C159654299 @default.
- W4313351624 hasConcept C167672396 @default.
- W4313351624 hasConcept C193419808 @default.
- W4313351624 hasConcept C202751555 @default.
- W4313351624 hasConcept C203014093 @default.
- W4313351624 hasConcept C2778107364 @default.
- W4313351624 hasConcept C2779341262 @default.
- W4313351624 hasConcept C3017875465 @default.
- W4313351624 hasConcept C32470452 @default.
- W4313351624 hasConcept C40767141 @default.
- W4313351624 hasConcept C54355233 @default.
- W4313351624 hasConcept C86803240 @default.
- W4313351624 hasConcept C8891405 @default.
- W4313351624 hasConcept C92087593 @default.
- W4313351624 hasConceptScore W4313351624C102230213 @default.
- W4313351624 hasConceptScore W4313351624C104317684 @default.
- W4313351624 hasConceptScore W4313351624C111599444 @default.
- W4313351624 hasConceptScore W4313351624C154317977 @default.
- W4313351624 hasConceptScore W4313351624C159047783 @default.
- W4313351624 hasConceptScore W4313351624C159654299 @default.
- W4313351624 hasConceptScore W4313351624C167672396 @default.
- W4313351624 hasConceptScore W4313351624C193419808 @default.
- W4313351624 hasConceptScore W4313351624C202751555 @default.
- W4313351624 hasConceptScore W4313351624C203014093 @default.
- W4313351624 hasConceptScore W4313351624C2778107364 @default.
- W4313351624 hasConceptScore W4313351624C2779341262 @default.
- W4313351624 hasConceptScore W4313351624C3017875465 @default.
- W4313351624 hasConceptScore W4313351624C32470452 @default.
- W4313351624 hasConceptScore W4313351624C40767141 @default.
- W4313351624 hasConceptScore W4313351624C54355233 @default.
- W4313351624 hasConceptScore W4313351624C86803240 @default.
- W4313351624 hasConceptScore W4313351624C8891405 @default.
- W4313351624 hasConceptScore W4313351624C92087593 @default.
- W4313351624 hasIssue "1_Supplement" @default.
- W4313351624 hasLocation W43133516241 @default.
- W4313351624 hasOpenAccess W4313351624 @default.
- W4313351624 hasPrimaryLocation W43133516241 @default.
- W4313351624 hasRelatedWork W1989386072 @default.
- W4313351624 hasRelatedWork W2052131992 @default.
- W4313351624 hasRelatedWork W2062787494 @default.
- W4313351624 hasRelatedWork W2098289998 @default.
- W4313351624 hasRelatedWork W2110370936 @default.
- W4313351624 hasRelatedWork W2137721990 @default.
- W4313351624 hasRelatedWork W2415603110 @default.
- W4313351624 hasRelatedWork W2998320773 @default.
- W4313351624 hasRelatedWork W4313351624 @default.
- W4313351624 hasRelatedWork W43273318 @default.
- W4313351624 hasVolume "190" @default.
- W4313351624 isParatext "false" @default.
- W4313351624 isRetracted "false" @default.
- W4313351624 workType "article" @default.