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- W4313351627 abstract "Abstract Listeria monocytogenes (L.m.) is a food borne disease-causing bacterium. The natural infection route in humans is through consumption of contaminated food. However, the rules governing L.m. dissemination and the subsequent innate and adaptive immune responses in the intestinal mucosa following oral infection have not been clarified. Thus, this study focused on immune responses to L.m. after oral infection using a murinized L.m. to mimic L.m. pathogenicity in humans. Initially, infection was limited to the gut mucosa, and antigen presentation predominantly occurred within mesenteric lymph nodes (MLN) and Peyer’s patches (PP). However, PP were dispensable for bacterial dissemination and clearance. L.m., but not Salmonella, was shuttled intracelluarly by Batf3-dependent DC from the intestine to the MLN, entering through the sub-capsular sinus into the interfollicular zones to eventually converge in the T cell zone. An organized architecture rapidly developed in the MLN with Ly6G+ neutrophils surrounding L.m., and with an outer zone of DCs and T cells, indicating a potential antigen presentation site. In addition, Batf3-dependent DC were also required for dissemination of irradiated L.m. to the MLN, suggesting the existence of a receptor-mediated system for L.m. acquisition. In sum, our data demonstrated organized immune responses to a unique L.m. dissemination pattern in the gut mucosa." @default.
- W4313351627 created "2023-01-06" @default.
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- W4313351627 date "2013-05-01" @default.
- W4313351627 modified "2023-09-29" @default.
- W4313351627 title "The dissemination of Listeria monocytogenes shuttled by Batf3-dependent DC from intestine to mesenteric lymph node following oral infection (P3226)" @default.
- W4313351627 doi "https://doi.org/10.4049/jimmunol.190.supp.124.24" @default.
- W4313351627 hasPublicationYear "2013" @default.
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