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- W4313351635 abstract "Abstract Cytotoxic T lymphocytes (CTL) can provide immunity between serologically-distinct strains of influenza virus, known as heterosubtypic immunity. Although the kinetics of the CTL response have been examined in detail by flow cytometry, changes in the distribution of different subsets of virus-specific CTL within the infected lungs are largely undocumented. We previously used parabiosis experiments to show that some virus-specific CD8 T cells, which maintain stable CD69 and CD103 expression, colonize the lungs and local lymph nodes during primary viral infection and remain sequestered from the circulation long after most symptoms of inflammation have resolved. Fluorescence microscopy has been used to follow changes in the distribution of these virus-specific Trm cells as they respond to secondary viral infection. We show that robust transforming growth factor-beta production selectively eliminates KLRG1+ effector CD8 T cells from the lung tissues, while CD103+ Trm cells persist in the airways. When the immune animals are reinfected with a new strain of influenza virus the CTL response is focused on the tissues around the infected airways. Circulating central memory CD8 T cells begin to divide in the local lymph nodes a few days later, but are insufficient to accelerate viral clearance in non-immune animals." @default.
- W4313351635 created "2023-01-06" @default.
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- W4313351635 date "2013-05-01" @default.
- W4313351635 modified "2023-10-14" @default.
- W4313351635 title "The anatomy of a protective CTL response in influenza virus infected lungs (P3204)" @default.
- W4313351635 doi "https://doi.org/10.4049/jimmunol.190.supp.124.13" @default.
- W4313351635 hasPublicationYear "2013" @default.
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