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- W4313351639 abstract "Abstract Vibrio parahaemolyticus, is the most common cause of bacterial seafood-related illness in the United States. Infection results in a self-limiting gastrointestinal illness, wound infection or for those chronically ill, may lead to systemic infection and death. The CDC reports a 115% increase in laboratory confirmed cases of Vibrio species in 2012 as compared to 1996-1998 surveillance data, with an increase of 47% alone since 2011. A dearth of literature exists regarding characterization of host immunity to infection. Furthermore, a murine model of orogastric infection has not been available, prohibiting studies characterizing the host response to infection. Toward that end, employing a newly developed streptomycin-pretreatment orogastric model of infection, we have begun investigating host immunity to infection. Utilizing streptomycin pretreatment, we have established infection as confirmed by organism recovery from exposed tissue and by an influx of inflammatory cells to the site of infection as compared to control groups; therefore documenting immunopathology. Additionally, changes in mucin production and lactorferrin were also confirmatory of immunopathology. Lastly, we are investigating the pro-inflammatory response to infection by assessing IL-1β, IL-6, MIP-1α, MIP-1β. This novel orogastric murine model of infection will remove barriers, allowing for the identification of essential immune parameters required for controlling infection." @default.
- W4313351639 created "2023-01-06" @default.
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- W4313351639 date "2013-05-01" @default.
- W4313351639 modified "2023-09-26" @default.
- W4313351639 title "Immunopathology in response to Vibrio parahaemolyticus infection. (P3222)" @default.
- W4313351639 doi "https://doi.org/10.4049/jimmunol.190.supp.124.22" @default.
- W4313351639 hasPublicationYear "2013" @default.
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