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- W4313351664 startingPage "139.8" @default.
- W4313351664 abstract "Abstract We have previously identified serum amyloid A (SAA) as a selective mitogen for regulatory T cells (Treg). However, the precise molecular mechanism by which SAA induces Treg proliferation has been unknown. Here we provide evidence that IL-1 and IL-6 are directly involved in the SAA-mediated reversal of Treg anergy. By engaging its several cognate receptors, SAA induces IL-1 and IL-6 secretion by monocytes. This monocyte-derived inflammatory milieu is required for Treg expansion as pharmacologic inhibition and genetic deletion of IL-1 and IL-6 abrogate the ability of SAA to reverse Treg anergy. Furthermore, while both IL-1 and IL-6 are required for ERK1/2 activation, only the former is necessary for AKT signaling in proliferating Treg. Collectively, these results point to a novel mechanism, by which SAA initiates a monocyte-dependent production of inflammatory cytokines to drive mitogenic signaling in Treg." @default.
- W4313351664 created "2023-01-06" @default.
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- W4313351664 date "2013-05-01" @default.
- W4313351664 modified "2023-09-27" @default.
- W4313351664 title "CD4+ T regulatory cells mitogenic signaling is activated by IL-1 and IL-6 produced by serum amyloid A-stimulated monocytes (P1037)" @default.
- W4313351664 doi "https://doi.org/10.4049/jimmunol.190.supp.139.8" @default.
- W4313351664 hasPublicationYear "2013" @default.
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