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- W4313351681 abstract "Abstract Toxoplasma gondii infects both hematopoietic and non-hematopoietic cells and can cause cerebral and ocular toxoplasmosis. Host protection likely acts at both cellular levels to control the parasite. CD40 is key for protection against cerebral and ocular toxoplasmosis. We determined if CD40 induces anti- T. gondii activity at the level of non-hematopoietic cells. Engagement of CD40 on various endothelial cells including human brain microvascular endothelial cells, human umbilical vein endothelial cells, a mouse endothelial cell line, as well as human and mouse retinal pigmented epithelial cells resulted in killing of T. gondii. CD40 stimulation increased expression of the autophagy proteins Beclin 1 and LC3 II, enhanced autophagy flux and led to recruitment of LC3 around the parasites. The late endosomal/lysosomal marker LAMP-1 accumulated around the parasite in CD40 stimulated cells. This was accompanied by killing of T. gondii dependent on lysosomal enzymes. Accumulation of LAMP-1 and killing of T. gondii were dependent on the autophagy proteins Beclin 1 and Atg7. Together, these studies revealed that CD40 induces toxoplasmacidal activity in various non-hematopoietic cells dependent on proteins of the autophagy machinery." @default.
- W4313351681 created "2023-01-06" @default.
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- W4313351681 date "2013-05-01" @default.
- W4313351681 modified "2023-09-27" @default.
- W4313351681 title "CD40 induces anti-T. gondii activity in non-hematopoietic cells via the autophagy pathway (P3050)" @default.
- W4313351681 doi "https://doi.org/10.4049/jimmunol.190.supp.125.3" @default.
- W4313351681 hasPublicationYear "2013" @default.
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