Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313351687> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W4313351687 endingPage "118.2" @default.
- W4313351687 startingPage "118.2" @default.
- W4313351687 abstract "Abstract Neutrophils have historically been viewed as phagocytes involved in direct killing of pathogens. Here, the mechanism of neutrophil recruitment and abscess formation during an infection was investigated by using a mouse model of Staphylococcus aureus cutaneous infection. Global gene expression analysis of S. aureus-infected skin of wild-type and IL-1R-deficient mice demonstrated that IL-1R activation was crucial for the upregulation of genes involved in neutrophil recruitment. IL-1β triggered IL-1R activation in this model and using IL-1β-reporter mice line, we surprisingly found that neutrophils were the predominant IL-1β-producing cells at the site of infection. S. aureus-induced IL-1β production by mouse and human neutrophils was mediated by the pattern recognition receptors, TLR2 and NOD2, and the ASC/NLRP3 inflammasome. Importantly, IL-1β-expressing neutrophils were essential for abscess formation and bacterial clearance since adoptive transfer of wild-type, but not IL-1β-deficient neutrophils, rescued the immune defects in IL-1β-deficient mice. Taken together, this study defines a new mechanism for abscess formation in which neutrophil-derived IL-1β, induced by TLR2, NOD2 and inflammasome activation, is required for effective neutrophil recruitment and host defense during a S. aureus skin infection." @default.
- W4313351687 created "2023-01-06" @default.
- W4313351687 creator A5002701262 @default.
- W4313351687 creator A5019384731 @default.
- W4313351687 creator A5037299249 @default.
- W4313351687 creator A5041317291 @default.
- W4313351687 creator A5044019365 @default.
- W4313351687 creator A5047110724 @default.
- W4313351687 creator A5050517005 @default.
- W4313351687 creator A5053549156 @default.
- W4313351687 creator A5068792317 @default.
- W4313351687 creator A5074919264 @default.
- W4313351687 creator A5075444437 @default.
- W4313351687 creator A5080742880 @default.
- W4313351687 creator A5082360434 @default.
- W4313351687 date "2012-05-01" @default.
- W4313351687 modified "2023-09-30" @default.
- W4313351687 title "Neutrophil-derived IL-1β is required for abscess formation in immunity against <i>Staphylococcus aureus</i> (118.2)" @default.
- W4313351687 doi "https://doi.org/10.4049/jimmunol.188.supp.118.2" @default.
- W4313351687 hasPublicationYear "2012" @default.
- W4313351687 type Work @default.
- W4313351687 citedByCount "0" @default.
- W4313351687 crossrefType "journal-article" @default.
- W4313351687 hasAuthorship W4313351687A5002701262 @default.
- W4313351687 hasAuthorship W4313351687A5019384731 @default.
- W4313351687 hasAuthorship W4313351687A5037299249 @default.
- W4313351687 hasAuthorship W4313351687A5041317291 @default.
- W4313351687 hasAuthorship W4313351687A5044019365 @default.
- W4313351687 hasAuthorship W4313351687A5047110724 @default.
- W4313351687 hasAuthorship W4313351687A5050517005 @default.
- W4313351687 hasAuthorship W4313351687A5053549156 @default.
- W4313351687 hasAuthorship W4313351687A5068792317 @default.
- W4313351687 hasAuthorship W4313351687A5074919264 @default.
- W4313351687 hasAuthorship W4313351687A5075444437 @default.
- W4313351687 hasAuthorship W4313351687A5080742880 @default.
- W4313351687 hasAuthorship W4313351687A5082360434 @default.
- W4313351687 hasConcept C134897094 @default.
- W4313351687 hasConcept C136449434 @default.
- W4313351687 hasConcept C203014093 @default.
- W4313351687 hasConcept C2776914184 @default.
- W4313351687 hasConcept C2777209026 @default.
- W4313351687 hasConcept C2779489039 @default.
- W4313351687 hasConcept C2781236682 @default.
- W4313351687 hasConcept C523546767 @default.
- W4313351687 hasConcept C54355233 @default.
- W4313351687 hasConcept C7573103 @default.
- W4313351687 hasConcept C86803240 @default.
- W4313351687 hasConcept C8891405 @default.
- W4313351687 hasConcept C89423630 @default.
- W4313351687 hasConceptScore W4313351687C134897094 @default.
- W4313351687 hasConceptScore W4313351687C136449434 @default.
- W4313351687 hasConceptScore W4313351687C203014093 @default.
- W4313351687 hasConceptScore W4313351687C2776914184 @default.
- W4313351687 hasConceptScore W4313351687C2777209026 @default.
- W4313351687 hasConceptScore W4313351687C2779489039 @default.
- W4313351687 hasConceptScore W4313351687C2781236682 @default.
- W4313351687 hasConceptScore W4313351687C523546767 @default.
- W4313351687 hasConceptScore W4313351687C54355233 @default.
- W4313351687 hasConceptScore W4313351687C7573103 @default.
- W4313351687 hasConceptScore W4313351687C86803240 @default.
- W4313351687 hasConceptScore W4313351687C8891405 @default.
- W4313351687 hasConceptScore W4313351687C89423630 @default.
- W4313351687 hasIssue "1_Supplement" @default.
- W4313351687 hasLocation W43133516871 @default.
- W4313351687 hasOpenAccess W4313351687 @default.
- W4313351687 hasPrimaryLocation W43133516871 @default.
- W4313351687 hasRelatedWork W1520314364 @default.
- W4313351687 hasRelatedWork W1921112241 @default.
- W4313351687 hasRelatedWork W2109056923 @default.
- W4313351687 hasRelatedWork W2129938274 @default.
- W4313351687 hasRelatedWork W2339263538 @default.
- W4313351687 hasRelatedWork W3210195559 @default.
- W4313351687 hasRelatedWork W4223893169 @default.
- W4313351687 hasRelatedWork W4254190765 @default.
- W4313351687 hasRelatedWork W4281774408 @default.
- W4313351687 hasRelatedWork W4313351687 @default.
- W4313351687 hasVolume "188" @default.
- W4313351687 isParatext "false" @default.
- W4313351687 isRetracted "false" @default.
- W4313351687 workType "article" @default.