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- W4313351689 abstract "Abstract We use co-immunoprecipitation and mass spectrometry to identify antiviral signaling networks which regulate innate immune responses. Fifty-eight baits were associated with 260 interacting proteins forming a Human Innate Immunity Interactome of 401 unique interactions; 21% of interactions were remodeled following RNA, DNA, or LPS stimulation. Overexpression and depletion analyses identified 22 novel genes which regulate NF-kB and ISRE reporter activity, viral replication, or virus-induced interferon production. The innate immune interactome provides a dynamic physical and regulatory network which serves as a foundation for mechanistic analysis of antiviral signaling and links innate immunity with other cell processes." @default.
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- W4313351689 date "2012-05-01" @default.
- W4313351689 modified "2023-09-25" @default.
- W4313351689 title "Mapping a dynamic innate immunity protein interaction network regulating type I interferon production (108.2)" @default.
- W4313351689 doi "https://doi.org/10.4049/jimmunol.188.supp.108.2" @default.
- W4313351689 hasPublicationYear "2012" @default.
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