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- W4313351723 abstract "Abstract The discovery of a trout EST bearing similarity to Igλ prompted an investigation of this previously uncharacterized isotype. Cloning and sequencing of gene-specific mRNA allowed the identification of two products. While the smaller product represented a fully spliced form, containing a variable segment (V), the joining segment (J), the constant region (C), and the 3’ UTR, the larger product was not fully spliced and contained a V segment, a 194bp intron, and a spliced J-C segment followed by the 3’ UTR. Phylogenetic analysis of the constant region confirmed that this new antibody isotype clustered with Igλ sequences of other species. Analysis of the recombination signaling sequences revealed that like Igλ in other species, the V and J segments are in the same transcriptional orientation with the V segment is followed by a heptamer-23bp spacer-nonamer while the J segment is preceded by a nonamer-12bp spacer-heptamer. In contrast to the Igκ and Igσ isotypes in trout that possess multiple VJC clusters, genomic analysis suggest that only a single Igλ VJC segment exists. Igλ accounts for only 1% to 3% of the total light chain expressions (IgκLC1 ~70%; IgσLC2 ~20%; IgκLC3~3%; IgλLC4~2%). Our identification of Igλ in rainbow trout shows that it is conserved throughout the teleost lineage. However, the role of the various Igλ splicing forms and whether the three Ig Heavy isotypes (IgM, IgD, IgT) demonstrate preferential light chain utilization still requires investigation." @default.
- W4313351723 created "2023-01-06" @default.
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- W4313351723 date "2012-05-01" @default.
- W4313351723 modified "2023-09-26" @default.
- W4313351723 title "The identification and expression of a new light chain isotype, Igλ, in rainbow trout, Oncorhynchus mykiss (160.17)" @default.
- W4313351723 doi "https://doi.org/10.4049/jimmunol.188.supp.160.17" @default.
- W4313351723 hasPublicationYear "2012" @default.
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