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- W4313351789 abstract "Abstract T cell receptor (TCR) diversity depends mainly on the hypervariable complementarity determining region 3 (CDR3) α and β loops generated by non-germline-encoded nucleotide insertions and/or deletions. To reveal alteration of CDR3 length during thymocyte development, we analyzed CDR3α and β length distributions in thymic CD4+CD8+ (DP), CD4+CD8- (CD4SP) and CD4-CD8+ (CD8SP) T cells from C57BL/6 (H-2b), C.B10 (BALB/c congenic, H-2b) and BALB/c (H-2d) mice. The CDR3α and β lengths shortened in both CD4SP and CD8SP cells of all strains tested and the extent of shortening varied considerably depending on V segment use. The CDR3α length shortened to the same extent between CD4SP and CD8SP cells whereas the shortening of CDR3β was more considerable in CD4SP than in CD8SP for C57BL/6 and C.B10, but the shortening was only slight for Balb/c. There was no correlation in the extent of CDR3 shortening between CD4SP and CD8SP cells. Interestingly, there was a good correlation in the extent of CDR3β shortening but not of CDR3α in CD8SP among different strains of mice, independent of MHC haplotype. These results suggest that the extent of CDR3 shortening is primarily determined by germline-encoded V segments and partially affected by allelic variation of MHC class I but not of MHC class II. This shows that T cells with shorter CDR3α and β lengths are preferably selected for the functional TCR repertoire, providing an intriguing insight into the interactions of the TCR and p-MHC ligand." @default.
- W4313351789 created "2023-01-06" @default.
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- W4313351789 date "2011-04-01" @default.
- W4313351789 modified "2023-10-16" @default.
- W4313351789 title "Shortening of complementarity determining region 3 of the T cell receptor α and β chains during thymocyte development (62.3)" @default.
- W4313351789 doi "https://doi.org/10.4049/jimmunol.186.supp.62.3" @default.
- W4313351789 hasPublicationYear "2011" @default.
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