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- W4313351854 abstract "Abstract Cannabis is widely used worldwide, yet its links to health outcomes are not fully understood. DNA methylation can serve as a mediator to link environmental exposures to health outcomes. We conducted an epigenome-wide association study (EWAS) of peripheral blood-based DNA methylation and lifetime cannabis use (ever vs. never) in a meta-analysis including 9,436 participants (7,795 European and 1,641 African ancestry) from seven cohorts. Accounting for effects of cigarette smoking, our trans-ancestry EWAS meta-analysis revealed four CpG sites significantly associated with lifetime cannabis use at a false discovery rate of 0.05 ( p < 5.85 × 10 −7 ): cg22572071 near gene ADGRF1 , cg15280358 in ADAM12 , cg00813162 in ACTN1 , and cg01101459 near LINC01132 . Additionally, our EWAS analysis in participants who never smoked cigarettes identified another epigenome-wide significant CpG site, cg14237301 annotated to APOBR . We used a leave-one-out approach to evaluate methylation scores constructed as a weighted sum of the significant CpGs. The best model can explain 3.79% of the variance in lifetime cannabis use. These findings unravel the DNA methylation changes associated with lifetime cannabis use that are independent of cigarette smoking and may serve as a starting point for further research on the mechanisms through which cannabis exposure impacts health outcomes." @default.
- W4313351854 created "2023-01-06" @default.
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- W4313351854 date "2022-12-31" @default.
- W4313351854 modified "2023-09-30" @default.
- W4313351854 title "Trans-ancestry epigenome-wide association meta-analysis of DNA methylation with lifetime cannabis use" @default.
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- W4313351854 doi "https://doi.org/10.1101/2022.12.29.22284040" @default.
- W4313351854 hasPublicationYear "2022" @default.