Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313353079> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W4313353079 endingPage "44.2" @default.
- W4313353079 startingPage "44.2" @default.
- W4313353079 abstract "Abstract IL-21 is a type I cytokine whose targets include both lymphoid and myeloid populations and whose role in host responses to pulmonary pathogens has not been evaluated. Pneumonia virus of mice (PVM) is a natural rodent pathogen that initiates a respiratory infection in mice that resembles severe human respiratory syncytial virus (RSV) disease. We demonstrate that IL-21 is expressed by CD4+ T cells in the lung following infection of animals with PVM. Examination of PVM-infected Il21r-/- mice revealed much less lung infiltration by neutrophils than was seen in WT mice, and consistent with this, Il21r-/- mice also had reduced levels of the chemokine CXCL1 in both bronchoalveolar lavage fluid and lung parenchyma. Both CD8+ and CD4+ T cells as well as γδ T cells were also reduced in PVM-infected Il21r-/- mice, even though CD8+ T cell cytokine responses were not diminished. Th17 cytokines were expressed at the same levels as in WT mice, but IL-6 production in response to PVM was diminished in Il21r-/- mice. Although virus recovery was similar in WT and Il21r-/- mice, the absence of IL-21 signaling conferred a survival advantage to Il21r-/- mice, indicating that IL-21 can contribute to a detrimental inflammatory state in the lung. Overall, our findings suggest that therapeutic manipulation of IL-21 signaling, such as IL-21 receptor blockade, may represent an immunomodulatory strategy for averting the negative sequelae of this and potentially other respiratory virus infections." @default.
- W4313353079 created "2023-01-06" @default.
- W4313353079 creator A5012950291 @default.
- W4313353079 creator A5027575666 @default.
- W4313353079 creator A5027972181 @default.
- W4313353079 creator A5029484872 @default.
- W4313353079 creator A5061037552 @default.
- W4313353079 creator A5065385960 @default.
- W4313353079 creator A5073472172 @default.
- W4313353079 creator A5082514194 @default.
- W4313353079 date "2012-05-01" @default.
- W4313353079 modified "2023-09-23" @default.
- W4313353079 title "IL-21 promotes the pathologic immune response to Pneumovirus infection (44.2)" @default.
- W4313353079 doi "https://doi.org/10.4049/jimmunol.188.supp.44.2" @default.
- W4313353079 hasPublicationYear "2012" @default.
- W4313353079 type Work @default.
- W4313353079 citedByCount "0" @default.
- W4313353079 crossrefType "journal-article" @default.
- W4313353079 hasAuthorship W4313353079A5012950291 @default.
- W4313353079 hasAuthorship W4313353079A5027575666 @default.
- W4313353079 hasAuthorship W4313353079A5027972181 @default.
- W4313353079 hasAuthorship W4313353079A5029484872 @default.
- W4313353079 hasAuthorship W4313353079A5061037552 @default.
- W4313353079 hasAuthorship W4313353079A5065385960 @default.
- W4313353079 hasAuthorship W4313353079A5073472172 @default.
- W4313353079 hasAuthorship W4313353079A5082514194 @default.
- W4313353079 hasBestOaLocation W43133530792 @default.
- W4313353079 hasConcept C105702510 @default.
- W4313353079 hasConcept C126322002 @default.
- W4313353079 hasConcept C13373296 @default.
- W4313353079 hasConcept C167672396 @default.
- W4313353079 hasConcept C203014093 @default.
- W4313353079 hasConcept C2522874641 @default.
- W4313353079 hasConcept C2777714996 @default.
- W4313353079 hasConcept C2777914695 @default.
- W4313353079 hasConcept C2777961210 @default.
- W4313353079 hasConcept C2778690821 @default.
- W4313353079 hasConcept C534529494 @default.
- W4313353079 hasConcept C71924100 @default.
- W4313353079 hasConcept C86803240 @default.
- W4313353079 hasConcept C8891405 @default.
- W4313353079 hasConcept C96525457 @default.
- W4313353079 hasConceptScore W4313353079C105702510 @default.
- W4313353079 hasConceptScore W4313353079C126322002 @default.
- W4313353079 hasConceptScore W4313353079C13373296 @default.
- W4313353079 hasConceptScore W4313353079C167672396 @default.
- W4313353079 hasConceptScore W4313353079C203014093 @default.
- W4313353079 hasConceptScore W4313353079C2522874641 @default.
- W4313353079 hasConceptScore W4313353079C2777714996 @default.
- W4313353079 hasConceptScore W4313353079C2777914695 @default.
- W4313353079 hasConceptScore W4313353079C2777961210 @default.
- W4313353079 hasConceptScore W4313353079C2778690821 @default.
- W4313353079 hasConceptScore W4313353079C534529494 @default.
- W4313353079 hasConceptScore W4313353079C71924100 @default.
- W4313353079 hasConceptScore W4313353079C86803240 @default.
- W4313353079 hasConceptScore W4313353079C8891405 @default.
- W4313353079 hasConceptScore W4313353079C96525457 @default.
- W4313353079 hasIssue "1_Supplement" @default.
- W4313353079 hasLocation W43133530791 @default.
- W4313353079 hasLocation W43133530792 @default.
- W4313353079 hasOpenAccess W4313353079 @default.
- W4313353079 hasPrimaryLocation W43133530791 @default.
- W4313353079 hasRelatedWork W2005666125 @default.
- W4313353079 hasRelatedWork W2045605122 @default.
- W4313353079 hasRelatedWork W2047209980 @default.
- W4313353079 hasRelatedWork W2126005292 @default.
- W4313353079 hasRelatedWork W2146036781 @default.
- W4313353079 hasRelatedWork W2377385340 @default.
- W4313353079 hasRelatedWork W2469884346 @default.
- W4313353079 hasRelatedWork W3035440422 @default.
- W4313353079 hasRelatedWork W3087626241 @default.
- W4313353079 hasRelatedWork W3204846410 @default.
- W4313353079 hasVolume "188" @default.
- W4313353079 isParatext "false" @default.
- W4313353079 isRetracted "false" @default.
- W4313353079 workType "article" @default.