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- W4313353163 abstract "Abstract As one of the six known IL-17 family members, IL-17A is a proinflammatory cytokine secreted by innate and adaptive immune cells. Especially IL-17A has been characterized as a key cytokine produced in a new CD4+ T helper subset, Th17 cells, which play an important role in host defense against specific pathogens. Effect of IL-17A is also implicated with pathogenic role of Th17 cells in autoimmunity and the chronic activation of IL-17-producing T helper cells can lead to autoimmune diseases. Indeed, increased levels of IL-17 have been observed in patients with autoimmune diseases including rheumatoid arthritis, multiple sclerosis, inflammatory bowel disease and psoriasis as shown by researchers. Hence development of a targeted therapeutic means or molecule that can effectively control IL-17 induction is crucial to prevent the initiation of IL-17-producing cell-mediated autoimmune diseases. In response to this, we have developed the IL-17A Prom/LUCPorter™ HEK 293 cell line, in which Renilla luciferase reporter gene is under control of the inducible IL-17A promoter. This cell line has been validated by exogenous expression of RORγ or RORγt construct, which can induce the IL-17A promoter activity leading to expression of luciferase reporter protein. This cell line is suitable for screening of antagonists for IL-17A induction which can be utilized as the therapeutic target molecules to control IL-17-producing cells." @default.
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- W4313353163 date "2012-05-01" @default.
- W4313353163 modified "2023-09-29" @default.
- W4313353163 title "Development of IL-17A promoter-based reporter cell line and activation of the cell line by exogenous expression of RORγ and RORγt. (59.12)" @default.
- W4313353163 doi "https://doi.org/10.4049/jimmunol.188.supp.59.12" @default.
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