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- W4313353294 abstract "Abstract The signal transducer and activator of transcription 1 (STAT1) is an essential part of signaling cascades induced by type I and II interferons. Deficiency of STAT1 results in heightened susceptibility to infections and autoimmunity in mouse and humans. While the role of IFNγ in T cell development is well known, the role of type I interferons in thymic development has largely remained unexplored. Here we show that STAT1 and IFNAR-deficient mice harbor a defect in medullary compartment characterized by a significant reduction in self-antigen presenting, AIRE expressing medullary thymic epithelial cells. Using a novel reporter mouse we demonstrate that constitutive IFNAR signaling is taking place in the thymic medulla in the absence of any infection or inflammatory signals. In addition, we found that RANK stimulation in thymic stromal cells results in the upregulation of IFNβ which in turn is inhibits RANK signaling thereby facilitating AIRE expression. Finally, we show that IRF7 is required for the induction of IFNβ by RANKL, and that IRF7-, but not IRF3-deficient mice display a defect in thymic architecture and medullary thymic epithelial cell differentiation similar to that observed in IFNAR- or STAT1-deficient animals. These results illustrate that a spatially and temporally coordinated crosstalk between the RANKL/RANK signaling pathway and the IRF7/IFNβ/IFNAR/STAT1 axis is essential for the differentiation of AIRE-expressing medullary thymic epithelial cells." @default.
- W4313353294 created "2023-01-06" @default.
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- W4313353294 date "2012-05-01" @default.
- W4313353294 modified "2023-09-25" @default.
- W4313353294 title "IRF7-dependent IFNβ production in response to RANK facilitates medullary thymic epithelial cell development. (60.3)" @default.
- W4313353294 doi "https://doi.org/10.4049/jimmunol.188.supp.60.3" @default.
- W4313353294 hasPublicationYear "2012" @default.
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