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- W4313353345 abstract "Abstract High mobility group box 1(HMGB1) is a nuclear protein that involves the interactions with DNA and chromatin regulation and transcription. HMGB1 is also a cytokine that can activate monocytes neutrophils involving in inflammation. In this study, we want to investigate the role of HMGB1 on cell migration on human fibroblast cell line -WI-38. After treated with HMGB1 1, 10, 100 ng/ml for 24h, we did not found obviously cytoxicity and proliferation effect on WI-38 cells by MTT and BrdU incorporation assay, respectively. We found that HMGB1 induced cell migration on WI38 by dose-dependent manner and caused MMP9 activation but not MMP2. Using specific inhibitor of protein kinases, we observed that extracellular signal related kinase (ERK) inhibitor- PD98059(2μM), c-Jun N-terminal kinase (JNK) inhibitor - SB203580(2μM), p38 mitogen activated protein kinase (p38) inhibitor-SP600125(2μM), phosphoinositide 3-kinase (PI3 kinase) inhibitor- LY294002(2μM), and NF-κB inhibitor-Bay117082(1μM) all showed the inhibition effect on HMGB1 induced WI-38 cells migration. We also found that HMGB1 induced ERK, JNK and p38 activated and increased the nucleus β-catenin expression by time-dependently. In the future, we will further investigate the mechanisms of HMGB1-induced cell migration on WI-38 including HMGB1 membrance receptors activation and related signaling pathway." @default.
- W4313353345 created "2023-01-06" @default.
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- W4313353345 date "2012-05-01" @default.
- W4313353345 modified "2023-10-14" @default.
- W4313353345 title "Human High Mobility Group Box 1 Induced Human Lung Fibroblasts Migration Through Activation PI3 kinase, MAPK, and NF-κB Signaling Pathway (173.31)" @default.
- W4313353345 doi "https://doi.org/10.4049/jimmunol.188.supp.173.31" @default.
- W4313353345 hasPublicationYear "2012" @default.
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