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- W4313353352 abstract "Abstract FCMR is a Fc receptor specific for pentameric IgM expressed at high levels by B cells. Although circulating IgM has profound effects on responses to pathogens, autoimmunity and B cell homeostasis, the biologic consequences of its binding to FCMR are poorly understood. We interrogated FCMR contributions to B cell function by studying mice lacking FCMR. FCMR transcripts are expressed at highest levels by follicular (FO) B cells and at much lower levels by developing B cells and other mature B cell subsets. FCMR-deficient mice have reduced numbers of developing B cells, splenic FO and peritoneal B-2 cells, but increased levels of peritoneal B-1a cells and autoantibodies. Following immunization, germinal center B cell and plasma cell numbers are increased. FCMR-deficient B cells are resistant to apoptosis induced by BCR ligation. Our studies demonstrate that FCMR functions are critical for B cell homeostasis, the prevention of autoreactive B cells and responsiveness to antigenic challenge." @default.
- W4313353352 created "2023-01-06" @default.
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- W4313353352 date "2012-05-01" @default.
- W4313353352 modified "2023-09-25" @default.
- W4313353352 title "The IgM Fc receptor, FCMR, promotes B cell development and modulates antigen-driven immune responses (176.9)" @default.
- W4313353352 doi "https://doi.org/10.4049/jimmunol.188.supp.176.9" @default.
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