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- W4313353955 abstract "Abstract Infection with bacterial pathogens can disrupt the intestinal mucosa that maintains a healthy immune system while keeping bacteria at bay. Using a model of oral infection with a murinized form of Listeria monocytogenes (Lm), our lab has identified a γδ T cell population that forms bona-fide memory and provides protection from re-infection. Since the precise mechanism of activation of most γδ T cells has remained elusive, we investigated the requirements for antigen presenting cells (APCs) in the activation of Lm-induced memory γδ T cells. Here, we show that several cells in the mesenteric lymph node (mLN), including dendritic cells (DCs), inflammatory monocytes and granulocytes, can act in conjunction to activate γδ T cells to express IL-17A, IFN-γ or both and induced their proliferation. This activation was largely cell contact dependent, but was augmented by soluble factors at the peak of primary and secondary γδ T cell responses, mainly by IL-1β but partially by IL-2 and IL-23. Moreover, using confocal microscopy we were able to image Lm-induced γδ T cells interacting with DCs and inflammatory monocytes in the interfollicular area of the mLNs soon after Lm challenge infection. We believe these results not only advance the understanding of γδ T cell biology, but also provide novel strategies to design protective vaccines for the intestinal mucosa." @default.
- W4313353955 created "2023-01-06" @default.
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- W4313353955 date "2013-05-01" @default.
- W4313353955 modified "2023-09-27" @default.
- W4313353955 title "Memory γδ T cells are activated by APCs in the mLN following oral <i> Listeria monocytogenes </i> infection (P3189)" @default.
- W4313353955 doi "https://doi.org/10.4049/jimmunol.190.supp.171.7" @default.
- W4313353955 hasPublicationYear "2013" @default.
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