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- W4313353974 abstract "Abstract HIV readily mutates and many of these mutations can be predicted based on the human leukocyte antigen class I (HLA-I) allele of the infected individual. Majority of these HLA-associated HIV polymorphisms may represent escape mutations whereby the epitope adapts to HLA-restricted pressure in every individual. Though these adapted epitopes have escaped recognition by some CD8 T cells, others may readily recognize them. However, to truly answer the question as to whether adapted epitopes induce CD8 T cell responses (primary response), acutely infected patient samples must be tested where we can accurately predict the infecting viral strain. We therefore tested whether CD8 T cells are induced when presented with either adapted or non-adapted epitopes encoded by the infecting viral strain in 8 HIV+ acute patients. Primary responses were more likely induced to non-adapted epitopes compared to the adapted (p=0.041). Furthermore, the few adapted epitopes that were able to elicit responses (primary or not) were predicted to exhibit a significantly higher HLA binding affinity compared to ones that did not elicit a response. CD8 T cells responding to adapted epitopes also shared similar magnitude, functional avidity, and polyfunctionality compared to those elicited to the non-adapted. Our results suggest at least some epitopes with HLA-associated mutations are still potentially immunogenic and may have important implications for T cell-based vaccine development." @default.
- W4313353974 created "2023-01-06" @default.
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- W4313353974 date "2013-05-01" @default.
- W4313353974 modified "2023-09-23" @default.
- W4313353974 title "Adapted HIV-1 epitopes can elicit functional CD8+ T cell responses (P6177)" @default.
- W4313353974 doi "https://doi.org/10.4049/jimmunol.190.supp.118.12" @default.
- W4313353974 hasPublicationYear "2013" @default.
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