Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313353987> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W4313353987 endingPage "116.8" @default.
- W4313353987 startingPage "116.8" @default.
- W4313353987 abstract "Abstract RNA with an exposed 5’-triphosphate (5’-ppp) and terminal double-stranded structures as found in cells during infection with many viruses, constitutes a strong activating ligand for the cytosolic pathogen sensor RIG-I. RNA binding and subsequent ATP hydrolysis by RIG-I are believed to be critical for downstream signaling. During its ligand-mediated activation, RIG-I has been suggested to form multimers but there is insufficient evidence on whether RIG-I is able to form higher-order oligomers on RNA and how multimerization affects signaling. In addition, RIG-I has been shown to translocate on 5’-ppp-dsRNA in an ATP-dependent manner and a precise role for the ATPase and associated RNA translocase activities in RIG-I activation has not been established. Using biochemical analyses of native RIG-I-RNA complexes, we show that RIG-I oligomerizes on this 5’-ppp dsRNA in an ATP hydrolysis-dependent manner. Importantly, there is a drastic reduction in ATP-dependent oligomerization of RIG-I on DI RNA with shorter dsRNA stems, correlating with the level of IFN-I activation by these RNAs. These results demonstrate a clear role for RIG-I ATPase in dsRNA length-dependent oligomer formation and provide a rationale for the ATP-driven translocase activity of RIG-I in stimulation of the IFN response." @default.
- W4313353987 created "2023-01-06" @default.
- W4313353987 creator A5004889712 @default.
- W4313353987 creator A5034088054 @default.
- W4313353987 creator A5057491089 @default.
- W4313353987 creator A5075480115 @default.
- W4313353987 creator A5090048523 @default.
- W4313353987 creator A5090654328 @default.
- W4313353987 date "2013-05-01" @default.
- W4313353987 modified "2023-10-18" @default.
- W4313353987 title "ATPase-driven oligomerization of RIG-I on an RNA ligand allows optimal induction of type I interferon (P1260)" @default.
- W4313353987 doi "https://doi.org/10.4049/jimmunol.190.supp.116.8" @default.
- W4313353987 hasPublicationYear "2013" @default.
- W4313353987 type Work @default.
- W4313353987 citedByCount "0" @default.
- W4313353987 crossrefType "journal-article" @default.
- W4313353987 hasAuthorship W4313353987A5004889712 @default.
- W4313353987 hasAuthorship W4313353987A5034088054 @default.
- W4313353987 hasAuthorship W4313353987A5057491089 @default.
- W4313353987 hasAuthorship W4313353987A5075480115 @default.
- W4313353987 hasAuthorship W4313353987A5090048523 @default.
- W4313353987 hasAuthorship W4313353987A5090654328 @default.
- W4313353987 hasConcept C104317684 @default.
- W4313353987 hasConcept C113035283 @default.
- W4313353987 hasConcept C116569031 @default.
- W4313353987 hasConcept C138626823 @default.
- W4313353987 hasConcept C141315368 @default.
- W4313353987 hasConcept C166703698 @default.
- W4313353987 hasConcept C170493617 @default.
- W4313353987 hasConcept C181199279 @default.
- W4313353987 hasConcept C185592680 @default.
- W4313353987 hasConcept C2191507 @default.
- W4313353987 hasConcept C23265538 @default.
- W4313353987 hasConcept C2776954689 @default.
- W4313353987 hasConcept C55493867 @default.
- W4313353987 hasConcept C67705224 @default.
- W4313353987 hasConcept C86803240 @default.
- W4313353987 hasConcept C95444343 @default.
- W4313353987 hasConcept C98539663 @default.
- W4313353987 hasConceptScore W4313353987C104317684 @default.
- W4313353987 hasConceptScore W4313353987C113035283 @default.
- W4313353987 hasConceptScore W4313353987C116569031 @default.
- W4313353987 hasConceptScore W4313353987C138626823 @default.
- W4313353987 hasConceptScore W4313353987C141315368 @default.
- W4313353987 hasConceptScore W4313353987C166703698 @default.
- W4313353987 hasConceptScore W4313353987C170493617 @default.
- W4313353987 hasConceptScore W4313353987C181199279 @default.
- W4313353987 hasConceptScore W4313353987C185592680 @default.
- W4313353987 hasConceptScore W4313353987C2191507 @default.
- W4313353987 hasConceptScore W4313353987C23265538 @default.
- W4313353987 hasConceptScore W4313353987C2776954689 @default.
- W4313353987 hasConceptScore W4313353987C55493867 @default.
- W4313353987 hasConceptScore W4313353987C67705224 @default.
- W4313353987 hasConceptScore W4313353987C86803240 @default.
- W4313353987 hasConceptScore W4313353987C95444343 @default.
- W4313353987 hasConceptScore W4313353987C98539663 @default.
- W4313353987 hasIssue "1_Supplement" @default.
- W4313353987 hasLocation W43133539871 @default.
- W4313353987 hasOpenAccess W4313353987 @default.
- W4313353987 hasPrimaryLocation W43133539871 @default.
- W4313353987 hasRelatedWork W109906158 @default.
- W4313353987 hasRelatedWork W1886265516 @default.
- W4313353987 hasRelatedWork W1965651642 @default.
- W4313353987 hasRelatedWork W1988143475 @default.
- W4313353987 hasRelatedWork W1999972298 @default.
- W4313353987 hasRelatedWork W2009127910 @default.
- W4313353987 hasRelatedWork W2135182337 @default.
- W4313353987 hasRelatedWork W2166361694 @default.
- W4313353987 hasRelatedWork W2256482451 @default.
- W4313353987 hasRelatedWork W4313353987 @default.
- W4313353987 hasVolume "190" @default.
- W4313353987 isParatext "false" @default.
- W4313353987 isRetracted "false" @default.
- W4313353987 workType "article" @default.