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- W4313353992 abstract "Abstract The live attenuated yellow fever virus 17D vaccine provides a well-controlled model to study T cell responses to an acute viral infection in humans. Here, we have studied the temporal dynamics, composition and character of the primary human T cell response to YFV. The acute YFV-specific effector CD8 T cell response was broad and complex, composed both of dominant responses that persisted into the memory population, as well as of transient subdominant responses that were not detected at the memory stage. Furthermore, HLA-A2- and HLA-B7-restricted YFV epitope-specific effector cells predominantly displayed a CD45RA-CCR7-PD- 1+CD27high phenotype, which transitioned into a CD45RA+CCR7-PD-1-CD27low memory population phenotype. The functional profile of the YFV-specific CD8 T cell response changed in composition as it matured from an effector- to a memory-type response, and tended to become less polyfunctional in the course of this transition. Interestingly, activation of CD4 T cells as well as FoxP3+ T regulatory cells in response to YFV vaccination preceded the kinetics of the CD8 T cell response. The present results contribute to our understanding of how immunodominance patterns develop, as well as the phenotypic and functional characteristics of the primary human T cell response to a viral infection as it evolves and matures into memory." @default.
- W4313353992 created "2023-01-06" @default.
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- W4313353992 date "2013-05-01" @default.
- W4313353992 modified "2023-10-16" @default.
- W4313353992 title "Temporal dynamics of the primary human T cell response to yellow fever virus 17D as it matures from an effector- to a memory-type response (P1406)" @default.
- W4313353992 doi "https://doi.org/10.4049/jimmunol.190.supp.117.3" @default.
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