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- W4313354005 abstract "Abstract Using a technique for the paired amplification of TCR α and β chains from single cells, we have discovered a surprising plasticity in the peripheral TCR repertoire, particularly under conditions of inflammation. This plasticity includes multiple instances of TCR revision, where changes are made in the TCR coding sequence by de novo rearrangement. Here we describe the induction of this process in murine CD8+ T cells derived from influenza-infected lungs and human T cells derived from CMV-infected individuals ex vivo or stimulated in single-cell cultures in vitro. Taking advantage of the co-expression of productive and non-productive Tcra alleles, we demonstrated secondary rearrangement in the TCRβ locus ex vivo, while the in vitro cultures demonstrated a remarkably high rate of revision following strong stimulation. Not surprisingly, revision was found to be RAG-dependent. Utilizing a model of peripheral deletion of RAG2, we showed that mice deficient in revision showed delayed onset and severity of disease in an experimental autoimmune encephalomyelitis (EAE) model, but also produced a less functional T cell response following infectious challenge. Thus, peripheral TCR revision appears to be a robust process that contributes to optimal T cell functionality during infection but may also contribute to the development of autoimmunity." @default.
- W4313354005 created "2023-01-06" @default.
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- W4313354005 date "2013-05-01" @default.
- W4313354005 modified "2023-09-27" @default.
- W4313354005 title "T cell receptor repertoire plasticity in peripheral CD8 T cells (P1446)" @default.
- W4313354005 doi "https://doi.org/10.4049/jimmunol.190.supp.117.23" @default.
- W4313354005 hasPublicationYear "2013" @default.
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