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- W4313354019 abstract "Abstract Follicular T helper (Tfh) cells are essential for germinal center (GC) reactions and somatic hypermutation of antibodies. Vaccination by the DNA prime-protein boost method typically yields antibodies with higher specificity and avidity than conventional approaches, and leads to production of neutralizing antibodies specific for conserved epitopes. Because Tfh cells are crucial for the development of plasma cells from the GC, we hypothesized DNA priming causes more Tfh cell differentiation, producing a more robust GC response. To test this, we primed mice with either gp120-encoding DNA or gp120 protein, three times, at two week intervals. Following a four week rest period, all mice received two gp120 protein boosts, two weeks apart. Priming with gp120-encoding DNA caused increased Tfh cell differentiation, compared to priming with protein alone, both after the priming injections, as well as after the final protein boosts. Additionally, GC B cell numbers were significantly increased with DNA priming. Mice receiving DNA priming had peak Tfh and GC B cell numbers earlier than mice receiving only protein. Furthermore, analysis of memory Th cells shows more Tfh cells being activated out of the memory cell pool when DNA priming is used. Our data suggests a role for Tfh cells in a DNA-prime, protein-boost vaccine strategy, and better expansion of Tfh cells may account for the superior antibody responses seen with this approach." @default.
- W4313354019 created "2023-01-06" @default.
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- W4313354019 date "2013-05-01" @default.
- W4313354019 modified "2023-10-14" @default.
- W4313354019 title "Enhanced expansion of follicular T helper cells following vaccination with gp120-encoding DNA (P4530)" @default.
- W4313354019 doi "https://doi.org/10.4049/jimmunol.190.supp.178.21" @default.
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