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- W4313354588 startingPage "139.12" @default.
- W4313354588 abstract "Abstract The administration of antigens into the anterior chamber (AC) of the eye induces a special form of antigen-specific peripheral immune tolerance termed AC-associated immune deviation (ACAID), which prevents delayed-type hypersensitivity (DTH) responses and other inflammatory responses. Type-II collagen (CII) is highly expressed in cartilage tissues and has been linked to Rheumatoid arthritis, aging, and osteoarthritis. To explore the potential for ACAID induction via CII, we checked for different signs of ACAID generation following the AC injection of CII in BALB/c mice. We hypothesized that the mechanism of ACAID induction involves efferent T regulatory cells (Tregs). Both local adoptive transfer (LAT) assays and DTH assays were performed. Results indicated that ACAID induction was driven by the AC injection of CII. Spleen cells of mice injected with CII in the AC significantly suppressed DTH responses. ACAID induction was mediated by efferent Tregs in the spleen. CII-mediated ACAID induction could have multiple therapeutic implications, especially in autoimmunity." @default.
- W4313354588 created "2023-01-06" @default.
- W4313354588 creator A5023335309 @default.
- W4313354588 creator A5068339461 @default.
- W4313354588 date "2013-05-01" @default.
- W4313354588 modified "2023-09-26" @default.
- W4313354588 title "The induction of anterior chamber associated immune deviation with Type II collagen (P1045)" @default.
- W4313354588 doi "https://doi.org/10.4049/jimmunol.190.supp.139.12" @default.
- W4313354588 hasPublicationYear "2013" @default.
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