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- W4313354619 abstract "Abstract CD4+FoxP3+ regulatory T cells are a subset of T cells that play central role in regulating inflammatory responses during many different immunological diseases. However the mechanisms of CD4+FoxP3+ regulatory T cells-mediated suppression remain controversial and poorly understood. Several studies have shown that CD4+FoxP3+ regulatory T cells can interact with and suppress a large number of cell types including CD4+ T cells and antigen presenting cells. For instance in vitro studies have shown that CD4+FoxP3+ regulatory T cells can inhibit cytokine production especially IL-2 production on CD4+ T cells hence the inhibition of CD4+ T cell proliferation; CD4+FoxP3+ regulatory T cells can also confer infectious tolerance by converting conventional T cells into functional FoxP3+ T cells in a cell contact TGF-β-dependent manner.In addition, CD4+FoxP3+ regulatory T cells suppress dendritic cell maturation and function by down-regulating the expression of co-stimulatory molecules CD80/CD86 via the interaction with CTLA-4.In our study, we have observed that CD4+FoxP3+ regulatory T cells may also modulate dendritic cell function via the PD-1:PD-L pathway. Dendritic cells that have been previously cultured with CD4+FoxP3+ regulatory T cells have decreased ability to support CD4+CD25- T cell proliferation and they can also induce higher level of FoxP3 expression in CD4+CD25- T cells." @default.
- W4313354619 created "2023-01-06" @default.
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- W4313354619 date "2013-05-01" @default.
- W4313354619 modified "2023-10-02" @default.
- W4313354619 title "CD4+FoxP3+ regulatory T cell-mediated suppression of dendritic cells (P1049)" @default.
- W4313354619 doi "https://doi.org/10.4049/jimmunol.190.supp.139.14" @default.
- W4313354619 hasPublicationYear "2013" @default.
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