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- W4313354741 endingPage "171.4" @default.
- W4313354741 startingPage "171.4" @default.
- W4313354741 abstract "Abstract We have previously reported that oral administration of Capsaicin (CP), the pungent component of chili peppers inhibits proliferation and activation of auto-reactive T cells and protects mice from development of Type-1 diabetes (T1D) in a dose dependent manner. Here, we demonstrate that orally administered CP leads to induction of CX3CR1+ macrophages specifically in lamina propria and in the pancreatic lymph nodes. CX3CR1+ macrophages also known as regulatory macrophages (Mregs) play a critical role in maintenance of immune homeostasis in the gut. Inflammation hampers the differentiation of monocytes into CX3CR1+ macrophages in the gut. However, the factors responsible for facilitating the differentiation into Mregs remain elusive. Using mice deficient in Vanilloid Receptor 1 (VR1), the receptor for CP, we report that VR1 is important for the differentiation of macrophages into Mregs, which subsequently play a key role in tolerance induction via the induction of immune-suppressive CD4+IL10+FoxP3- Tr1 cells. This process culminates in providing protection from T1D in NOD mice. This study elucidates how a common food additive, CP, can act as a potent immune-modulatory agent and ameliorate autoimmune disease like T1D." @default.
- W4313354741 created "2023-01-06" @default.
- W4313354741 creator A5009557222 @default.
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- W4313354741 date "2013-05-01" @default.
- W4313354741 modified "2023-09-28" @default.
- W4313354741 title "Modulation of intestinal macrophages for control of Type 1 diabetes (P3183)" @default.
- W4313354741 doi "https://doi.org/10.4049/jimmunol.190.supp.171.4" @default.
- W4313354741 hasPublicationYear "2013" @default.
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