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- W4313354803 abstract "Abstract The ability of dendritic cells to mediate CD40L-dependent CD4+ T cell help for the induction and support of effector CD8+ cytotoxic T lymphocyte responses greatly depends on activation signals they received during maturation. In addition to being 'programmed' to produce high levels of IL-12p70, we found that DC matured under type 1 polarizing conditions also form intricately branched tunneling nanotube-like structures upon CD40L stimulation. These formations can create extensive interconnected networks between cells, a process we termed 'reticulation'. Importantly, this response was found to occur exclusively in mature type 1 polarized DC and was uniquely induced by recombinant CD40L or CD40L-expressing cells. Using live-cell time-lapse confocal imaging, we were able to determine that these structures can support the transfer of endosomes, HIV-1 virus-like particles, and nano-beads representing antigen from 'donor' to 'recipient' type 1 polarized DC. This induction of the process of DC reticulation potentially represents a novel helper function of CD40L, as it likely enhances intercellular communication and contributes to the superior capacity of type 1 polarized DC to induce cellular immune responses. This active immune cell process may also be utilized by viruses such as HIV-1 for cell-to-cell spread." @default.
- W4313354803 created "2023-01-06" @default.
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- W4313354803 date "2013-05-01" @default.
- W4313354803 modified "2023-10-01" @default.
- W4313354803 title "CD40L induces networks of branching tunneling nanotube-like structures exclusively in type 1 polarized dendritic cells (P4187)" @default.
- W4313354803 doi "https://doi.org/10.4049/jimmunol.190.supp.112.27" @default.
- W4313354803 hasPublicationYear "2013" @default.
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