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- W4313354811 startingPage "171.5" @default.
- W4313354811 abstract "Abstract Intraepithelial lymphocytes in tissues such as the skin and intestine play key roles in maintaining barrier integrity via the production of growth factors and cytokines. Obesity and type 2 diabetes induce defects in tissue repair and barrier function causing chronic nonhealing wounds and more severe cases of colitis. Our studies show that as obesity and type 2 diabetes progress, animals exhibit a dramatic decline in the number of epithelial T cells due to impaired T cell homeostatic proliferation. To understand how obesity impacts gene expression in the epithelium, we performed gene chip analysis and qPCR on cells isolated from the epithelium of obese mice. Our studies show that the normal gene expression program in both epithelial cells and intraepithelial T cells becomes disrupted. While T cells exhibit a gene profile indicative of exhaustion with a reduced ability to make growth factors and cytokines, the neighboring epithelial cells downregulate cell adhesion molecules and members of the IL-1 family such as IL-1F6. Returning the animals to a low fat diet does not rapidly restore the ability of T cells to recover their numbers and improve their function. However, blocking the low level of chronic inflammation that occurs with obesity improves T cell function in repair. These data indicate that controlling the myriad of epithelial complications associated with obesity will require turning down chronic inflammation and restoring the normal cellular program in intraepithelial T cells so immune responses at the critical barrier tissues are preserved." @default.
- W4313354811 created "2023-01-06" @default.
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- W4313354811 date "2013-05-01" @default.
- W4313354811 modified "2023-10-17" @default.
- W4313354811 title "Epithelial T cell gene expression is altered by obesity and Type 2 diabetes causing T cell exhaustion and barrier dysfunction (P3185)" @default.
- W4313354811 doi "https://doi.org/10.4049/jimmunol.190.supp.171.5" @default.
- W4313354811 hasPublicationYear "2013" @default.
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