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- W4313354910 abstract "Abstract Aim: Polarization of macrophages to M1 or M2 phenotypes will dictate the effectiveness of host responses against specific infections. Membrane-associated RING-CH (MARCH1) has been shown to be implicated in the activation of antigen presenting cells and is readily induced by the anti-inflammatory cytokine IL-10. Here, we set out to investigate the role of MARCH1 in the activation of macrophages and its implication in host responses. Results: We show that MARCH1-deficient bone-marrow-derived macrophages exhibit a bias toward M1 polarization as assessed by quantitative real-time PCR, cytometric bead array (CBA) and flow cytometry. Furthermore, a macrophage population showing intermediate surface markers (CD11bint and F4/80int) between M1 and M2 was observed in the peritoneal cavity of MARCH1-deficient mice. In addition, these mice were found to be more susceptible to LPS-induced shock and exhibited higher pro-inflammatory cytokine production in their serum as monitored by CBA. Finally, MARCH1-deficient mice showed an enhanced clearing of leishmania parasites in the spleen at 21 and 28 days post infection. Conclusion: These results show that MARCH1 contributes to the polarization and functional plasticity of macrophages. Conflict of Interest disclosure: No conflict to declare." @default.
- W4313354910 created "2023-01-06" @default.
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- W4313354910 date "2013-05-01" @default.
- W4313354910 modified "2023-09-30" @default.
- W4313354910 title "MARCH1 regulates macrophage polarization and host responses against parasite infections (P1271)" @default.
- W4313354910 doi "https://doi.org/10.4049/jimmunol.190.supp.56.18" @default.
- W4313354910 hasPublicationYear "2013" @default.
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