Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313354988> ?p ?o ?g. }
Showing items 1 to 70 of
70
with 100 items per page.
- W4313354988 endingPage "68.24" @default.
- W4313354988 startingPage "68.24" @default.
- W4313354988 abstract "Abstract Background: Laquinimod (LAQ) is a novel drug that has been in clinical trial in systemic lupus erythematosus (SLE), an autoimmune disease characterized by nephritis mediated in part by autoantibodies. Aim: We investigated the immunomodulatory properties of LAQ on lupus nephritis in NZB x NZW F1 (BWF1) mice, a murine model for SLE. Methods: Six-month old BWF1 female mice were treated orally 3 times a week with LAQ 25 mg/kg or water. Results: All LAQ-treated animals survived up to 10 weeks after treatment vs 0% survival in controls. No LAQ-treated mouse had proteinuria by week 10 while it was significantly high (3 g/L) in 100% of controls by week 7 after treatment. Examination of kidney specimens showed significantly decreased histologic inflammation, damage, immunoglobulin and C3 deposition in LAQ-treated vs controls. LAQ significantly reduced macrophages (CD11b+) and their expression of MHC, and these cells produced higher levels of IL-10 and lower TNF-alfa vs controls, a phenotype characteristic of anti-inflammatory type II macrophages. In addition, increased frequency of CD11b+Ly6C+Ly6G+ and CD11b+Ly6C+Ly6G- cells was found in LAQ-treated vs controls and these cells suppressed CD4+ T cell proliferation, what characterizes them as myeloid suppressor cells. Conclusion: LAQ suppressed lupus nephritis, improved animals’ survival and increased both anti-inflammatory macrophages and myeloid suppressor cells. Thus, LAQ is a promising therapeutic for human lupus nephritis." @default.
- W4313354988 created "2023-01-06" @default.
- W4313354988 creator A5035764571 @default.
- W4313354988 creator A5048917449 @default.
- W4313354988 creator A5072870816 @default.
- W4313354988 creator A5081980656 @default.
- W4313354988 creator A5088781566 @default.
- W4313354988 date "2013-05-01" @default.
- W4313354988 modified "2023-09-27" @default.
- W4313354988 title "Laquinimod suppression of lupus nephritis in BWF1 mice associates in renal tissue with increase of myeloid suppressor cells and switch of macrophages to anti-inflammatory type II (P5193)" @default.
- W4313354988 doi "https://doi.org/10.4049/jimmunol.190.supp.68.24" @default.
- W4313354988 hasPublicationYear "2013" @default.
- W4313354988 type Work @default.
- W4313354988 citedByCount "0" @default.
- W4313354988 crossrefType "journal-article" @default.
- W4313354988 hasAuthorship W4313354988A5035764571 @default.
- W4313354988 hasAuthorship W4313354988A5048917449 @default.
- W4313354988 hasAuthorship W4313354988A5072870816 @default.
- W4313354988 hasAuthorship W4313354988A5081980656 @default.
- W4313354988 hasAuthorship W4313354988A5088781566 @default.
- W4313354988 hasConcept C121608353 @default.
- W4313354988 hasConcept C126322002 @default.
- W4313354988 hasConcept C159654299 @default.
- W4313354988 hasConcept C171779818 @default.
- W4313354988 hasConcept C179185449 @default.
- W4313354988 hasConcept C203014093 @default.
- W4313354988 hasConcept C2776912625 @default.
- W4313354988 hasConcept C2776914184 @default.
- W4313354988 hasConcept C2777058396 @default.
- W4313354988 hasConcept C2779134260 @default.
- W4313354988 hasConcept C2779282312 @default.
- W4313354988 hasConcept C2779912601 @default.
- W4313354988 hasConcept C553184892 @default.
- W4313354988 hasConcept C55721878 @default.
- W4313354988 hasConcept C71924100 @default.
- W4313354988 hasConceptScore W4313354988C121608353 @default.
- W4313354988 hasConceptScore W4313354988C126322002 @default.
- W4313354988 hasConceptScore W4313354988C159654299 @default.
- W4313354988 hasConceptScore W4313354988C171779818 @default.
- W4313354988 hasConceptScore W4313354988C179185449 @default.
- W4313354988 hasConceptScore W4313354988C203014093 @default.
- W4313354988 hasConceptScore W4313354988C2776912625 @default.
- W4313354988 hasConceptScore W4313354988C2776914184 @default.
- W4313354988 hasConceptScore W4313354988C2777058396 @default.
- W4313354988 hasConceptScore W4313354988C2779134260 @default.
- W4313354988 hasConceptScore W4313354988C2779282312 @default.
- W4313354988 hasConceptScore W4313354988C2779912601 @default.
- W4313354988 hasConceptScore W4313354988C553184892 @default.
- W4313354988 hasConceptScore W4313354988C55721878 @default.
- W4313354988 hasConceptScore W4313354988C71924100 @default.
- W4313354988 hasIssue "1_Supplement" @default.
- W4313354988 hasLocation W43133549881 @default.
- W4313354988 hasOpenAccess W4313354988 @default.
- W4313354988 hasPrimaryLocation W43133549881 @default.
- W4313354988 hasRelatedWork W1452338814 @default.
- W4313354988 hasRelatedWork W1993116843 @default.
- W4313354988 hasRelatedWork W2108207992 @default.
- W4313354988 hasRelatedWork W2136532720 @default.
- W4313354988 hasRelatedWork W2388451375 @default.
- W4313354988 hasRelatedWork W2389059287 @default.
- W4313354988 hasRelatedWork W2741898385 @default.
- W4313354988 hasRelatedWork W2808229450 @default.
- W4313354988 hasRelatedWork W2972528799 @default.
- W4313354988 hasRelatedWork W3128241465 @default.
- W4313354988 hasVolume "190" @default.
- W4313354988 isParatext "false" @default.
- W4313354988 isRetracted "false" @default.
- W4313354988 workType "article" @default.