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- W4313355000 abstract "Abstract The type I or invariant NKT iNKT) cells are among the first responders in various infectious and inflammatory settings and bridge innate and adaptive immunity. iNKT cells quickly producing numerous cytokines such as IFNγ, IL-17, IL-4, IL-13, and IL-10 to regulates innate and adaptive immune responses. iNKT cells contribute to the pathogenesis of allergy and asthma, autoimmune diseases, graft-versus-host disease, infections, cancer, and obesity as well as other diseases. While it is well established that the iVα14 T cell receptor and IL-15 receptor and numerous transcription factors are critically involved in iNKT cell development and effector lineage differentiation, the signaling events bridging the receptors and the transcription factors are poorly understood. We have recently demonstrated that diacylglycerol kinases α and ζ play crucial roles in iNKT cell development and that DGKα and ζ negatively control not only the well-known Ras-Erk1/2 and PKCθ-IKK-NFκB pathways but also mTOR signaling in T cells. We now reveal that mTOR signaling and its tight regulation play crucial roles in iNKT cells as deficiency of either mTOR or its regulator TSC1 profoundly impacts iNKT cell development and effector lineage differentiation." @default.
- W4313355000 created "2023-01-06" @default.
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- W4313355000 date "2013-05-01" @default.
- W4313355000 modified "2023-10-16" @default.
- W4313355000 title "Signal control of iNKT development and effector lineage differentiation (P1208)" @default.
- W4313355000 doi "https://doi.org/10.4049/jimmunol.190.supp.188.7" @default.
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